profound moment profound mystery profound political profound question profound questions profound realm profound reform profound respect profound sadness profound sense profound shift profound significance profound silence profound social profound sorrow profound spiritual profound statement profound thing profound things profound thought profound transformation profound transformations profound truth profound truths profound understanding profound way profound ways profound wisdom profound words profoundest profoundly profoundly affect profoundly affected profoundly affects profoundly altered profoundly change profoundly changed profoundly deaf profoundly different profoundly disturbing profoundly grateful profoundly human profoundly impacted profoundly important profoundly influenced profoundly moved profoundly moving profoundly sad profoundly shocked profoundly sorry profoundly touched profoundly wrong profs profumo profundity profuse profuse bleeding profuse sweating profusely illustrated profusion prog prog rock progenitor progenitor cell progenitor cells progenitors progeny progeria progesterone progesterone and estrogen progesterone cream progesterone hormone progesterone levels progesterone receptor progesterone receptors progestin progestins progestogen progetti progetto prognoses prognosis prognosis and treatment prognosis can prognosis depends prognosis for patients prognosis is excellent prognosis is good prognosis is poor prognosis may prognostic prognostic factor prognostic factors prognostic information prognostic marker prognostic value prognostication prognostications prognosticator