significant industrial significant influence significant information significant infrastructure significant inhibitory significant initiatives significant injuries significant injury significant innovation significant innovations significant input significant inroads significant intellectual significant interaction significant interactions significant interest significant interference significant internal significant international significant investment significant investments significant investor significant involvement significant issue significant issues significant items significant jewish significant job significant jump significant knowledge significant lack significant landmark significant lead significant leap significant learning significant legal significant legislative significant length significant level significant levels significant life significant limitation significant limitations significant link significant liver significant local significant loss significant losses significant majority significant management significant manner significant manufacturing significant margin significant mark significant market significant market power significant market share significant material significant meaning significant media significant media attention significant medical significant memory significant milestone significant milestones significant military significant minority significant modification significant modifications significant moment significant moments significant momentum significant money significant morbidity significant mortality significant move significant movement significant muscle significant muslim significant national significant natural significant need significant negative significant negative impact significant new significant news significant noise significant number significant number of cases significant number of people significant numbers significant obstacle significant obstacles significant oil significant one significant ones significant only significant operating significant operational