significant opportunities significant opportunity significant opposition significant organizational significant other significant others significant outcomes significant overall significant overlap significant pain significant part significant participation significant parts significant pay significant penalties significant people significant percentage significant performance significant period of time significant periods significant person significant personal significant pharmacokinetic significant physical significant piece significant pieces significant place significant places significant player significant point significant points significant policy significant political significant popularity significant population significant populations significant portion significant portion of the population significant portions significant position significant positive significant positive impact significant potential significant power significant practical significant predictor significant presence significant pressure significant price significant private significant problem significant problems significant processing significant product significant production significant productivity significant professional significant profit significant profits significant progress significant progress has significant progress has been made significant progress made significant progress was made significant project significant projects significant property significant proportion significant provisions significant psychological significant public significant public health significant quality significant quantities significant quantity significant questions significant rain significant rainfall significant rate significant reason significant reasons significant recent significant recovery significant reduction significant reductions significant reform significant reforms significant regional significant regulatory significant relationship significant relationships significant relief significant religious significant renovation significant repercussions significant research significant reserves significant residual significant resistance