significant resources significant response significant responsibilities significant responsibility significant restrictions significant restructuring significant result significant results significant return significant returns significant revenue significant revenues significant revision significant revisions significant rise significant risk significant risk factor significant risk factors significant risks significant role significant roles significant safety significant sales significant saving significant savings significant scale significant scientific significant scope significant seasonal significant section significant security significant security incidents significant service significant setback significant share significant shareholder significant shareholders significant shift significant shifts significant shortage significant shortcomings significant side significant side effects significant signs significant similarities significant site significant sites significant size significant slowdown significant snowfall significant social significant socio-economic significant source significant sources significant space significant species significant stake significant statistical significant step significant steps significant strategic significant strength significant strengthening significant stress significant strides significant structural significant success significant sum significant sums significant support significant swelling significant symbol significant symptom significant symptoms significant table significant task significant tax significant technical significant technological significant temperature significant test significant therapeutic significant thing significant things significant threat significant threats significant time significant to me significant to you significant tool significant toxicity significant trade significant trading significant traffic significant training significant transactions significant transboundary significant transformation significant trauma