significantly improves significantly improving significantly in recent years significantly increase significantly increased significantly increased risk significantly increases significantly increases the risk significantly increasing significantly influence significantly influenced significantly influences significantly inhibit significantly inhibited significantly interfere significantly involved significantly large significantly larger significantly less significantly less likely significantly lighter significantly limit significantly limited significantly limits significantly longer significantly low significantly lower significantly lower levels significantly lower than that of significantly lowers significantly modified significantly modify significantly more significantly more effective significantly more expensive significantly more likely significantly negative significantly older significantly over the past decade significantly over time significantly positive significantly prolonged significantly raise significantly raised significantly reduce significantly reduce the risk significantly reduced significantly reduces significantly reduces the risk significantly reducing significantly related significantly revised significantly shortened significantly shorter significantly slower significantly smaller significantly speed up significantly superior significantly weakened significantly weaker significantly worse significantly worsened significantly younger signification significations significative signified signifier signifies signifies the beginning signifies the end signifor signify signify by saying signify something signify the end signifying signifying nothing signin signing signing a contract signing a deal signing a document signing a lease signing a memorandum signing a new signing a peace signing a petition signing a treaty signing a two-year contract signing agreements signing an agreement signing and ratifying signing anything signing authorities signing authority signing autographs signing bonus signing bonuses