significant danger significant data significant date significant dates significant day significant debt significant decision significant decisions significant decline significant decrease significant decreases significant deficiencies significant degradation significant degree significant delay significant delays significant demand significant demographic significant departure significant design significant deterioration significant determinant significant development significant developmental significant developments significant deviation significant deviations significant difference significant difference between groups significant difference was found significant difference was observed significant differences significant differences between groups significant differences exist significant differences were found significant differences were observed significant difficulties significant difficulty significant digit significant digits significant direct significant disability significant disadvantage significant disadvantages significant discomfort significant discount significant discounts significant discoveries significant discovery significant discrepancies significant discussion significant disease significant disparities significant disruption significant distance significant distinction significant distress significant domestic significant donor significant drawback significant drawbacks significant driver significant drop significant drug significant early significant earthquake significant earthquakes significant ecological significant economic significant economic growth significant economic impact significant effect significant effects significant efficiency significant effort significant efforts significant efforts have significant element significant elements significant elevation significant emotional significant emphasis significant employment significant energy significant engineering significant enhancement significant enough significant environmental significant environmental aspects significant environmental benefits significant environmental effects significant environmental impact significant environmental impacts significant error significant errors significant ethnic significant european significant even significant event