Examples of 'activating mutations' in a sentence
Meaning of "activating mutations"
activating mutations - In genetics, activating mutations are changes in a gene that lead to increased activity or function of the gene, often associated with diseases such as cancer
How to use "activating mutations" in a sentence
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activating mutations
Kras activating mutations are the first mutations detected.
This disease resulted from two alleles activating mutations on nucleotide excision repair.
Activating mutations of the kras oncogene are common in both lung and colon tumors.
Colorectal cancer is most commonly initiated by activating mutations in the Wnt signaling cascade.
Activating mutations in BRAF have been reported in a variety of malignancies.
Tumour regression is observed in mouse models of enforced expression of these EGFR activating mutations.
Patients with activating mutations in the EGFR kinase domain more likely to respond.
The mutations that are found in PIK3CA appear to be activating mutations.
FGFR often activating mutations also change progress of disease and sensitivity to the administered therapy.
FLT3 kinase mutations associated with hematologic malignancies are activating mutations.
Patients with EGFR activating mutations and ALK translocations were excluded from recruitment.
Preferably, the KIT inhibitor inhibits preferably KIT harboring activating mutations.
Activating mutations at BRAF.
As shown by the above results, the FGFR3 activating mutations were frequent in bladder carcinomas.
Activating mutations in the EGFR gene and response to EGFR-TKIs.
See also
First-line treatment of non-squamous NSCLC with EGFR activating mutations in combination with erlotinib.
Activating mutations of FGFR3 have also been identified in bladder carcinoma cases.
Initially, we studied the activating mutations of the PIK3CA gene.
Activating mutations in RET play an important role in tumorigenesis in medullary thyroid cancer ( MTC ).
It is also characterized by frequent activating mutations of the KIT gene [ 5 ].
In humans activating mutations of FGFR-3 are the primary cause of genetic dwarfism.
At least 50 % of common sporadic VMs are also caused by somatic activating mutations in TIE2.
Furthermore, activating mutations of the FGFR3 are detected mainly in bladder cancer specimens.
Thirty-five percent of patients diagnosed with JMML show activating mutations in PTPN11.
There are two types of activating mutations in FLT3 described in patients with leukemia.
Activating mutations in FGFR4 have been identified in rhabdomyosarcoma see Shukla, N., et.
Patients with EGFR activating mutations in whom previous chemotherapy has not worked ;.
Activating mutations of ¿ - catenin ( ctnnb1 ) gene have been reported in several human malignancies.
Moreover, ACVR1/ALK2 activating mutations have been identified as well.
Moreover, activating mutations in HER3 have highlighted the role of HER3 as a direct therapeutic target.
Two other activating mutations have been found in the intracellular juxtamembrane region of KIT, ie.
The FGFR3 activating mutations appear to be frequently associated with tumours that do not progress.
In addition, activating mutations in p85 have been identified in ovarian and colon cancer.
In particular activating mutations in FGFR2 have been identified in 10 % of endometrial tumours.
Furthermore, activating mutations in Trk 's are present in 7 % of cancers.
Conversely, rare activating mutations of GLK reduce this threshold resulting in familial hyperinsulinism [ 6,7 ].
Activating mutations in PDGFRA have been detected in 5-12 % of Gastrointestinal stromal tumor.
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Examples of using Mutations
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These mutations most likely are compensatory mutations
Most loss of function mutations are selected against
Examples of using Activating
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Braking torque activating the overload protector
Activating and deactivating the outer rings
Command buttons for activating various functions
