Examples of 'aglycosylated' in a sentence
Meaning of "aglycosylated"
aglycosylated (verb) - the process of removing glycosylation from a molecule, usually a protein
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- Not glycosylated
How to use "aglycosylated" in a sentence
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aglycosylated
The term further includes glycosylated and aglycosylated antibodies.
Aglycosylated antibodies can be produced by a variety of methods known in the art.
Expression in bacterial cells typically provides for an aglycosylated antibody.
The humanised aglycosylated antibodies in accordance with the invention have therapeutic value.
Preferably the antibody is aglycosylated.
An humanized aglycosylated IgG1 antibody that specifically binds c-Kit and that comprises.
The antibody may be aglycosylated.
Furthermore, aglycosylated antibodies may be produced in bacterial cells which lack the necessary glycosylation machinery.
The invention also includes a cell line which expresses an aglycosylated antibody according to the invention.
The method according to claim 1, wherein the immunoglobulin constant region is aglycosylated.
Typically, bacteria produce aglycosylated proteins.
The pharmaceutical composition according to claim 1, wherein the immunoglobulin Fc fragment is aglycosylated.
Preferably, the antibody is an aglycosylated antibody.
An aglycosylated IgG antibody having a binding affinity for the CD3 antigen complex.
The Fc region is further engineered to increase the stability of the aglycosylated molecule.
See also
The pharmacokinetics ( PK ) profile of stabilized aglycosylated antibodies was determined in cynomolgus monkeys.
In another embodiment, a molecule of the invention is aglycosylated.
Thus, with respect to the present objects, an aglycosylated or deglycosylated Fc fragment is preferred.
In some embodiments, an antibody of the invention is aglycosylated.
Aglycosylated antibody specific for the mouse CD8 antigen was included as a negative control.
In particular embodiments, the antibody is aglycosylated.
An aglycosylated antibody according to Claim 9 having a heavy chain variable domain which comprises.
In certain embodiments, the antibody to be pegylated is an aglycosylated antibody.
Accordingly, an aglycosylated Fc domain of human IgG4 is the most highly preferred drug carrier.
In certain aspects, the antibody to be pegylated is an aglycosylated antibody.
An aglycosylated antibody according to Claim 19 which is monovalent.
In some embodiments, the antibody to be pegylated is an aglycosylated antibody.
An aglycosylated antibody according to any of Claims 1 to 13 for use in therapy.
Preferably, the immunoglobulin constant region may be aglycosylated.
In one embodiment, milk-derived glycosylated and aglycosylated chimeric preparations to the original GW mAb.
The antibody fragment of claim 1 wherein the antibody fragment is aglycosylated.
Comprises a variant Fc region and is aglycosylated or deglycosylated ; or.
The antibodies may also be optimized for enhanced functionality and / or solution properties in aglycosylated form.
In some embodiments, the constant region is aglycosylated for N-linked glycosylation.
The observed lower melting temperature negatively impacts various biophysical properties of the aglycosylated IgG1.
Accordingly, in a specific embodiment, an aglycosylated hybrid nuclease-albumin molecule is produced in a CHO cell.
Specifically included within the definition of " antibody " are aglycosylated antibodies.
Accordingly, a human IgG4-derived aglycosylated Fc region may be much more preferably used.
In yet other embodiments, immunoglobulins of the invention comprise an aglycosylated constant region.
An ' irrelevant ' aglycosylated antibody specific for the murine CD8 antigen was included as a negative control.
Preferably, the immunoglobulin Fc region may be aglycosylated.
More preferred are aglycosylated IgG2 Fc and IgG4 Fc fragments, combinations thereof and hybrids thereof.
Preferably, the immunoglobulin Fc region may be a human aglycosylated IgG4 Fc region.
The usefulness of the aglycosylated Fc goes beyond the IL-2 mutein Fc-fusion context.
The insulin conjugate of claim 1, wherein the immunoglobulin Fc region is aglycosylated.
AlphaScreen assay showing binding of aglycosylated alemtuzumab Fc variants to human V158 FcYRIIIa.
The insulin analog conjugate according to claim 8, wherein the immunoglobulin Fc region is aglycosylated.
In still other embodiments, the constant region is aglycosylated for N-linked glycosylation.
The aglycosylated hu342 antibody also comprises a huIgG4 Fc domain.
In some aspects, the Tmls described above are for aglycosylated versions of the antibody.
