Examples of 'alpha-helical' in a sentence
Meaning of "alpha-helical"
Alpha-helical (adjective) - Alpha-helical refers to the structure of a protein or molecule that forms a helix shape, where the backbone of the molecule is coiled in a spiral. This type of structure is common in proteins and plays a crucial role in their functions and interactions
How to use "alpha-helical" in a sentence
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alpha-helical
Proteins with alpha-helical transmembrane anchors.
This residue strongly induces formation of alpha-helical structure.
An alpha-helical polypeptide containing multiple crosslinks.
Circular dichroism spectroscopy indicates a high alpha-helical content.
Novel alpha-helical stitched polypeptides are described.
A pharmaceutical composition comprising a substantially alpha-helical polypeptide of claim 2.
The alpha-helical region also includes crosslinkable sites.
When a protein crosses the lipid bilayer it adopts an alpha-helical configuration.
Alpha-helical peptides suitable for activating or inhibiting cell death.
In a particular aspect, a first domain includes or consists of an amphipathic alpha-helical structure.
Alpha-helical segments are separated by segments wherein the chain is less constrained.
Tropomyosin is a two-stranded alpha-helical coiled coil protein found in cell cytoskeletons.
Transmembrane domains are rich in hydrophobic residues, and typically have an alpha-helical structure.
The domain adopts an alpha-helical structure consisting of two four-helix bundles.
Certain hydrophobic and hydrophilic amino acid residues are preferred in constructing alpha-helical peptides.
See also
Rigid linkers such as alpha-helical linkers do not afford the necessary flexibility.
The linkers may comprise modifications that stabilize an alpha-helical structure of said peptide.
The alpha-helical portion of the spike protein is associated with the cell membrane.
A pharmaceutical composition comprising a substantially alpha-helical inventive polypeptide and a pharmaceutically acceptable excipient is described.
This class includes membrane proteins that are tethered to the membrane vía alpha-helical transmembrane anchors.
The helical agent is preferably an alpha-helical agent, which preferably has a lipophilic and a lipophobic phase.
The protein scaffold molecules of the present invention fold into an alpha-helical coiled coil structure.
A substantially alpha-helical polypeptide of the formula, wherein,.
Figure 2 illustrates the principles of a triple-stranded, alpha-helical coiled coil complex.
Alpha-helical structure and reversible folding / unfolding.
A schematic representation of a synthetic peptide in an alpha-helical conformation is shown in Figure 2.
Let us try an alpha-helical membrane, see if we can combine then.
Gα subunits consist of two domains, the GTPase domain, and the alpha-helical domain.
The FERM domain is followed by an alpha-helical domain and a hydrophilic tail.
An alpha-helical polypeptide of the formula, or a pharmaceutically acceptable salt thereof ;.
Principles of a triple-stranded, alpha-helical coiled coil complex.
Firstly, they are transmembrane proteins with a single transmembrane spanning domain - presumably alpha-helical.
Let us try an alpha-helical membrane, see if we can combine them.
Firstly, they are transmembrane proteins with a single transmembrane spanning domain-presumably alpha-helical.
The secondary structures are shown as alpha-helical and beta-stranded regions.
Examples of our successful designs are “ Peptabody ”, a high-avidity binding protein, and uniformly soluble alpha-helical nanofibrils.
The proteins are highly hydrophilic, with a mainly alpha-helical structure held together by 3 disulfide bridges.
The alpha-helical coiled coil forms a special type of 3-D structural framework ( structural motif, fold ).
The figure provides a helical wheel representation of triple-stranded, alpha-helical coiled coil structures.
Trifluoroethanol ( TFE ), an inducer of alpha-helical conformation was added, and the spectra were recorded.
All embodiments of the present invention relate to ' single-chain ' yet ' triple-stranded ' alpha-helical coiled coil structures.
Such modifications may increase the alpha-helical content of the peptide by the " helix dipole effect ".
Similarly, pressure treated Product B formulation retained native alpha-helical structure ( Data not shown ).
The design of amphipathic peptide structures ( e.g. alpha-helical polypeptides ) is known in the art.
In humans, 27 % of all proteins have been estimated to be alpha-helical membrane proteins.
G119R additionally increases the alpha-helical tendencies of the sequence.
