Examples of 'alphavirus' in a sentence
Meaning of "alphavirus"
alphavirus (noun): A genus of viruses, including those that cause various diseases in animals and humans such as Chikungunya and Ross River virus
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- Any virus of the genus Alphavirus (family Togaviridae).
How to use "alphavirus" in a sentence
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alphavirus
This condition is termed alphavirus polyarthritis syndrome.
Alphavirus vector or replicon systems have been described.
The viral protein is an alphavirus structural protein.
Alphavirus vectors for influenza virus vaccines.
It is optionally engineered to express alphavirus structural proteins.
Alphavirus particles and methods for preparation.
The virus belongs to the alphavirus group.
Alphavirus infections are spread by insect vectors such as mosquitoes.
Promoterless cassettes for expression of alphavirus structural proteins.
There are no alphavirus vaccines currently available.
It may also be engineered to express alphavirus structural proteins.
Use of alphavirus in preparation of antitumor drugs.
In certain embodiments the heterologous antigen is an alphavirus antigen.
The alphavirus particles may be delivered by liposomal system.
Infection with salmonid alphavirus.
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Alphavirus vectors typically are constructed in a format known as a replicon.
The invention provides alphavirus vectors as defined in the claims.
Alphavirus replicase genes are expressed in addition to the vaccine insert.
Appropriate attenuating mutations depend upon the alphavirus used.
Alphavirus vectors can be gene delivery vectors in other contexts.
A polynucleotide can comprise a subgenomic promoter from any alphavirus.
Chimeric alphavirus replicon particles.
The envelope protein may be derived from the second alphavirus.
Alphavirus vectors may be gene delivery vectors in other contexts.
The second layer construct is an alphavirus vector construct as described above.
Alphavirus replicon particles matched to protein antigens as immunological adjuvants.
Sindbis virus is a member of the alphavirus genus of the togaviridae family.
Alphavirus and alphavirus replicon particle formulations and methods.
Appropriate attenuating mutations will be dependent upon the alphavirus used.
An alphavirus replicon vector comprising.
The replicon may also be engineered to express alphavirus structural proteins.
Collecting the alphavirus particles produced from the helper cell.
Several evidence underscore the importance of muscle disease progression induced by alphavirus.
Alphavirus replicon particles are administered as a booster some time after priming.
Described herein are chimeric alphavirus particles that exhibit efficient structural interactions.
Alphavirus envelope glycoproteins e.
The morphology and morphogenesis of the alphavirus genus is generally quite uniform.
Crude or clarified alphavirus replicon particles may be concentrated and purified by chromatographic techniques e.
Recombinant viral vectors for prevention and protection against alphavirus infection.
The invention further provide an alphavirus vector system comprising an translational enhancer element.
This promoter element is quiescent in the absence of productive cytoplasmic alphavirus replication.
A preparation of alphavirus replicon particles may be purified by a chromatographic purification process as described above.
Such inefficiency is also relevant to the in vitro transcription of alphavirus expression vectors.
In some aspects methods for providing alphavirus particles comprising a modified capsid protein are described.
The envelope may also be an envelope from a heterologous source such as an alphavirus envelope.
In yet another example four different alphaviruses are used to prepare the chimeric alphavirus particle.
These infectious supernatants are then used to transduce a fresh monolayer of alphavirus packaging cells.
The present invention also provides infectious alphavirus particles produced by the method described above.
This leads to higher expression and higher titer of packaged infectious recombinant alphavirus vector.
A method of purification for alphavirus replicon particles may comprise at least two chromatographic purification steps.
