Examples of 'amino acid modifications' in a sentence
Meaning of "amino acid modifications"
amino acid modifications: Changes made to the structure of amino acids, the building blocks of proteins, which can impact the function and behavior of proteins in biological systems
How to use "amino acid modifications" in a sentence
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amino acid modifications
Conservative amino acid modifications are described herein.
Energy calculation refers to the process by which amino acid modifications are scored.
Combining amino acid modifications is thought to be particularly desirable.
Preferred modifications of the invention are amino acid modifications and glycoform modifications.
The amino acid modifications are preferably conservative substitutions.
Nomenclature for amino acid modifications.
Such amino acid modifications are discussed in more detail below.
Modifications described herein include amino acid modifications and glycoform modifications.
Amino acid modifications.
In one embodiment amino acid modifications may be combined.
Amino acid modifications may be made to the Fc region of an immunoglobulin.
Further encompassed are amino acid modifications in the hinge region.
The amino acid modifications may not substantially alter the activity of the endoribonuclease.
Analogs comprising further amino acid modifications are contemplated herein.
The amino acid modifications are preferably selected from the group of deletions and substitutions.
See also
Modifications of the invention include amino acid modifications and glycoform modifications.
Such amino acid modifications can be determined empirically by a skilled artisan.
Variants disclosed herein are defined according to the amino acid modifications that compose them.
Some amino acid modifications of the above lists are key modifications.
The derivative of claim 1, wherein the analogue has a maximum of five amino acid modifications.
Modifications include amino acid modifications and glycoform modifications.
In some embodiments, B is modified by up to three amino acid modifications.
The amino acid modifications may be any of those described herein.
In one embodiment, B is modified by up to three amino acid modifications.
Yet there are innumerable amino acid modifications that are detrimental or deleterious to proteins.
The L2 protein forming the VIP preferably has a minimal number of amino acid modifications.
Such amino acid modifications are reviewed in Beck et al.
In some embodiments, is synthesized, comprises non-natural amino acid modifications.
Exemplary amino acid modifications of Fc domains also are provided elsewhere herein.
The analogue of any one of embodiments 1-8 which has a minimum of three amino acid modifications.
These amino acid modifications result in an altered binding of FVIIa to TFPI.
In certain embodiments, GLP-1/glucagon agonist peptides provided herein are stabilized vía amino acid modifications.
The amino acid modifications described herein result in an altered binding of FVIIa to TFPI.
For example, the glucagon antagonist may comprise one, two, or three conservative amino acid modifications.
Preferably, said amino acid modifications improve affinity to FcyRIIb.
For example, the Class 4 peptide may comprise one, two, or three conservative amino acid modifications.
Amino acid modifications in the CDRs are sometimes referred to as “ affinity maturation ”.
Briefly, single and / or multiple amino acid modifications were introduced and analyzed to optimize, e . g.
The derivative of any one of embodiments 1-167, wherein the analogue has eight amino acid modifications.
In exemplary aspects, the amino acid modifications occur at a position other than position 1.
The analogue of any one of embodiments 1-28, wherein the amino acid modifications are additions.
Polypeptides with amino acid modifications ( i.e. muteins ) may be desirable in a variety of circumstances.
The analogue of any one of embodiments 1-28, wherein the amino acid modifications are deletions.
In some cases, amino acid modifications in the CDRs are referred to as “ affinity maturation ”.
Pre-optimized Fc variants have preferably 1 to 4 amino acid modifications as compared to the wild-type Fc.
The endoribonuclease can comprise amino acid modifications ( e.g., substitutions, deletions, additions etc ).
In a specific embodiment, B comprises one or both of the amino acid modifications ( v ) and ( vi ).
Additional specific non-limiting examples of amino acid modifications include OX40 subsequences and fragments.
Alternatively, the analog can comprise such amino acid modifications at position 27 and / or 28.
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