Examples of 'amorphous compound' in a sentence
Meaning of "amorphous compound"
amorphous compound - a compound that lacks a definite form or shape; often used in chemistry to describe substances that do not have a fixed crystalline structure
How to use "amorphous compound" in a sentence
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amorphous compound
This caused the compound to precipitate as amorphous compound.
A white amorphous compound.
This lowering in concentration is considered attributable to crystallization of the amorphous compound in water.
The resulting desired compound as a gray amorphous compound was directly used for the next reaction.
The amorphous Compound A was dissolved in a minimum amount of methanol or ethanol at room temperature.
Carriers usable herein include those as described above in connection with amorphous compound A.
In some embodiments, the amorphous compound is in the form of a solid dispersion.
A solid dispersion comprising substantially amorphous Compound 2.
In contrast, the amorphous compound does not give a definite diffraction pattern.
The crystalline solid may be substantially free of amorphous Compound 1.
To obtain the crystalline powder, the amorphous compound was treated at different temperatures.
In some embodiments, the crystalline solid is substantially free of amorphous Compound 1.
The complex of claim 40 wherein the amorphous compound is poorly soluble in crystalline form.
Furthermore, according to the present invention, there is provided a process for producing amorphous compound A.
In a particular embodiment, amorphous Compound 2 is formulated as a solid dosage form.
See also
In some embodiments, a lyophilate comprises amorphous Compound I.
Accordingly, amorphous Compound 1 is useful for intravascular and intramuscular delivery.
In certain embodiments, the present invention provides amorphous Compound 1 substantially free of crystalline Compound 1.
The purified amorphous compound of formula ( I ) is crystallized by selecting water as a crystallization solvent.
Also, described herein is a method of preparation of amorphous Compound I and its characterization.
The amorphous compound obtained is referenced AHC3.
For example, Compound 1 is present as an amorphous compound as a component of a solid amorphous dispersion.
Figure 6 is a differential scanning calorimetry trace of amorphous Compound I.
Methods of preparing amorphous Compound 1 are described in the Examples section, infra.
Alternatively Form VI may be in admixture with amorphous compound of formula ( I ).
Example 5 Preparation of Amorphous Compound 1 Amorphous Compound 1 was prepared by lyophilization from an aqueous solution.
Therefore, the composite oxide layer 5 contains an amorphous compound.
In another embodiment, compositions comprising amorphous Compound 1 Form X and one or more excipients are provided.
In other embodiments, compound 2 is a crystalline solid substantially free of amorphous compound 2.
The lyophilized drug product is amorphous Compound I, and more preferably the sodium salt thereof.
The product of this method 1b is crystalline compound ( 1 ) substantially free of amorphous compound.
The generator according to claim 6, wherein the amorphous compound is represented by the formula,.
Advantageously, amorphous Compound 1, as described herein, has enhanced water solubility.
The material according to claim 1, wherein the amorphous compound is represented by the formula,.
Fig . 12 is a graph showing one embodiment of an IR absorption curve of an amorphous compound.
In some embodiments, the dispersion includes amorphous Compound 1 or substantially amorphous Compound 1.
A lubricant, wherein the solid dispersion comprises about 25 mg of substantially amorphous Compound 1.
In some aspects, the dispersion includes amorphous Compound 1 or substantially amorphous Compound 1.
In certain embodiments, the solid dispersion comprises about 75 mg of substantially amorphous Compound 1.
Conveniently, the amorphous compound is dissolved in the solvent at a temperature of normally at least 10°C.
Figure 7 shows a TG thermogram of amorphous compound 1.
Amorphous Compound 1 may be substantially free of crystalline Compound 1.
In some embodiments, the crystalline form of Compound 1 is substantially free of amorphous Compound 1.
In some embodiments, amorphous Compound 2 is substantially free of the S-isomer.
The product is purified by chromatography ( Ethyl acetate / dichloromethane ) in order to produce amorphous compound ( I ).
To prepare a capsule preparation containing 100 mg of the amorphous compound produced in Example 1 per preparation.
The amorphous compound I decomposed significantly at temperatures above 5°C.
The X-ray powder diffraction pattern of amorphous Compound 1 is depicted in Figure 3.
The entire list of peaks, or a subset thereof, may be sufficient to characterize amorphous Compound ( I ).
In another embodiment, amorphous Compound 1 Form X, or a composition thereof, is administered to a subject.
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