Examples of 'antibody variants' in a sentence
Meaning of "antibody variants"
antibody variants - Refers to different forms or versions of antibodies that may exist due to mutations or other factors
How to use "antibody variants" in a sentence
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antibody variants
Deploy all antibody variants and stop it.
A variety of radioactive isotopes are available for the production of radioconjugated antibody variants.
Antibody variants and fragments thereof.
Purifying mixtures of antibody variants with modified isolectric points.
Antibody variants with modified Fc glycans and altered effector function may be produced.
Cysteine engineered antibody variants.
Such antibody variants may be prepared by affinity maturation.
The present invention encompasses antibody variants of antibodies described herein.
The antibody variants disclosed herein may also be formulated as liposomes.
Preparation of antibody variants.
The antibody variants disclosed herein may also be formulated as immunoliposomes.
Methods for production and screening of antibody variants are well known in the art.
Certain antibody variants with improved or diminished binding to FcRs are described.
The library is then screened to identify any antibody variants with the desired affinity.
The antibody variants of the invention may be used as affinity purification agents.
See also
The concentration range of the antibody variants used in Fig.
Other antibody variants having one or more amino acid substitutions are provided.
Figure 2 is a schematic representation of oligonucleotides useful in generating antibody variants.
Methods for making antibody variants are generally available in the art.
Such variable domains may be incorporated into antibodies, antibody mimetics or antibody variants.
Methods for masking antibody variants are generally available in the art.
Labeling with maleimide dyes is only one example of site-specific conjugation on these antibody variants.
Humanized antibody variants were designed that either included or omitted the back mutations.
Methods for production and screening of antibody variants are well-known in the art.
Monoclonal antibody variants of the present disclosure may be obtained by conventional genetic engineering methods.
Additional combinations of phage-derived mutations could yield antibody variants with similarly improved affinities.
The antibody variants of the present invention have superior inhibitory activity to cancer cell proliferation.
Other therapeutic regimens may be combined with the administration of the anti-ErbB antibody variants.
Then antibody variants constructs were amplified by PCR and cloned into the expression vector.
For example, antigen binding fragments can be derived from antibodies or antibody variants described supra.
Antibody Variants Amino acid sequence variants of the antibodies provided herein are contemplated.
According to an embodiment, the antibody variants of the present invention are a humanized antibody.
Antibody variants may be screened using one or more cell-based or in vivo assays.
This figure shows the binding properties of several chimeric and recombinant humanized anti-S1P antibody variants.
Preferably, antibody variants are used to treat breast cancer.
FIG . 2 is a schematic representation of oligonucleotides useful in generating antibody variants.
That is, antibody variants are not added exogenously to the cells.
Binding activity of a first complement component C1q with antibody variants was measured using a flow cytometer.
The following antibody variants were included in the binding assay experiment,.
The rhuMAb HER2 SPSFF chromatography column resolves antibody variants.
Alternatively, antibody variants or fragments as defined herein above may be used.
SDS-PAGE analysis of antibody variants.
Ab3 antibody variants at various concentrations were then added to the wells.
The present invention concerns antibody variants, preferably anti-HER2 antibody variants.
Antibody Variants In certain aspects, amino acid sequence variants of the antibodies are contemplated.
The present disclosure also provides antibody variants of 6G with amino acid sequences depicted in Table 3.
Antibody variants of G1 with amino acid sequences depicted in Table 6 can also be used.
This figure shows the comparative binding of 3A4 humanized antibody variants and the murine 3A4.
Anti-tfpi antibody variants with differential binding across ph range for improved pharmacokinetics.
Examples Example 1 - Generation of humanized CD3 antibodies and non-activating antibody variants.
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