Examples of 'apelin' in a sentence
Meaning of "apelin"
apelin (noun) - A small peptide hormone involved in regulating blood pressure and cardiovascular function
Show more definitions
- A peptide that is the endogenous ligand for the G-protein-coupled APJ receptor
How to use "apelin" in a sentence
Basic
Advanced
apelin
Apelin fusión proteins are also administered to treat retinopathy.
It has been reported that apelin has an inotropic effect on heart.
Apelin has therapeutic effects in neonatals exposed to hyperoxia.
Also provided is a method for providing an apelin analog according to the invention.
Apelin is able to improve the energy use of the cell.
Primary targets for the neovascularization properties of apelin are heart and leg muscle.
For apelin receptor agonists multiple therapeutic areas exist.
The short circulating time of unmodified apelin peptides and transient inotropic effects were anticipated.
An apelin receptor agonist is also described as a hot flash suppressant.
One aspect of the disclosure provides a polypeptide comprising an apelin peptide fused to a multimerizing component.
Apelin is a well known protein.
The placental expression of apelin and APJ was increased in obese mice.
Apelin fusión proteins are administered to promote or increase survival of neurons.
The amino acid and nucleic acid sequences of Apelin are well known in the art.
Synthetic apelin mimetics for the treatment of heart failure.
See also
The invention relates to compositions and methods for treating a disease or disorder associated with Apelin.
Apelin and its receptor are expressed in embryonal and adult tissues.
The invention further provides kits that comprise a therapeutically effective amount of the pegylated Apelin.
Aged apelin knockout mice develop progressive impairment of cardiac contractility.
Fc-fusion proteins may comprise an apelin peptide as described herein.
Apelin peptide may promote obesity through adipose tissue expansion.
Methods, Stability of apelin analogs in rat plasma.
Apelin blood levels.
In another example, the pegylated molecule comprises is an oligomeric Apelin.
Apelin peptides are among the most potent endogenous positive inotropic agents.
In one example, the pegylated molecule comprises a monomeric Apelin.
Chronic apelin treatment triggers an amelioration of both lipid and glucose metabolism.
In addition to its physiologic effects, apelin was also involved in the pathogenesis of HF.
The apelin peptide may be modified to minimize degradation and to enhance serum stability.
Of interest, incomplete oxidation was not significantly increased by chronic apelin treatment Fig.
Presence of labeled apelin fusión proteins may be detected in vivo for diagnosis purposes.
The invention also provides pharmaceutical compositions that comprise a therapeutically effective amount of the pegylated Apelin 36.
Apelin fusión proteins are administered to treat HIV infection.
The placental expression of apelin and APJ was studied by quantitative RT-PCR.
Apelin treatment also has no effect on the rate of palmitate incorporation into TG Fig.
In addition, stimulation of APJ with apelin leads to recruitment of B-arrestins Lee et al.
Apelin Fusion Proteins Methods of making fusión proteins are known in the art.
The molecule of embodiment 1, wherein said pegylated Apelin comprises monomeric Apelin.
The measures of apelin concentrations in plasma and colostrum were performed by ELISA.
Figure 1 A and B, Consequences of a chronic apelin treatment on muscle genes expression.
Chronic apelin treatment in HFD mice improves muscle insulin sensitivity.
The invention also provides the pegylated Apelin 36 for use as a medicament.
Such modifications to apelin peptides do not alter their ability to activate the APLNR.
The molecule of embodiment 1, wherein said pegylated Apelin is a mono-pegylated Apelin.
Effect of chronic apelin treatment in HFD mice on muscle mitochondrial activity and density.
Apelin has anti-inflammatory effects in hyperoxia treated rat pups.
The disclosure also provides apelin Fc-fusion proteins comprising variant Fc domain sequences.
Apelin fusión proteins of the invention have increased half-life compared to apelin peptides.
In animal studies, apelin exerts vasodilation and positive inotropic actions.
Apelin and its receptor are expressed in majority of tissues and organs, including cardiovascular system.
