Examples of 'apob' in a sentence
Meaning of "apob"
apob is a protein that plays a crucial role in lipid metabolism
How to use "apob" in a sentence
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apob
High levels of ApoB are related to heart disease.
More than twice that of apoB.
Values for ApoB siRNA are shown.
In certain embodiments disclosed herein are methods for reducing ApoB in an individual.
The apoB gene is expressed in the liver and intestine.
Peptides and derivatives from ApoE and ApoB were a particular focus.
Serum ApoB levels determination.
Numbering above the sequences corresponds to the human apoB sequence.
It is the dominant ApoB protein in the small intestine of most mammals.
Normalization for loading was carried out using mouse apoB gene controls.
Serum levels of apoB and apoE are not different between genotypes.
This enabled them to monitor the movement of ApoB complexes in larval zebrafish.
Percent inhibition of ApoB secretion is determined by normalizing data to vehicle treated wells.
In certain embodiments the invention provides methods for reducing ApoB in an individual.
A link between the apoB gene and abetalipoproteinemia has been excluded in several families.
See also
The siRNA dose was titrated and the effect on serum ApoB content was measured.
The animal with the highest apoB plasma level was used in subsequent studies.
The new research suggests that there might be a whole other benefit to reducing apoB.
The human apoB transcript was expressed and edited in the liver of the transgenic mice.
The first biomolecule specifically interacts with OxPL and the second biomolecule specifically interacts with apoB.
ApoB containing particle levels were not influenced by diet.
The ELISA for apoB is performed as follows.
ApoB really tells us how many particles of lipid you have in your blood.
Inhibition of apoB and TG secretion.
Serum ApoB protein levels were determined by standard sandwich ELISA methods.
In certain embodiments, the target is ApoB.
ApoB is the only major apolipoprotein that does not transfer between lipoprotein particles.
In some embodiments, the siRNA targets the ApoB gene.
HDL and apoB cholesterol concentrations.
Table 8 presents data for peptides that are derived from apoB.
ApoB formation is required to initially form LDL molecules in the blood.
Multicompartmental modeling of pulse-chase studies was used to analyze cellular apoB kinetics.
ApoB is the part of the LDL particle that binds to the receptor.
The exposed lipids are oxidized, which in turn modify the ApoB structure.
As expected, rabbit apoB mRNA was detected in all tissues examined.
However, under basal conditions lovastatin had no effect on the secretion rate of apoB.
In certain examples, short antisense compounds targeted to an ApoB nucleic acid are short gapmers.
The shortage of triglyceride and / or cholesteryl ester could inhibit the secretion of apoB.
Formulated therapies that reduce ApoB can be useful for treating lipid-related disorders.
In this study the researchers showed that calorie-restricted mice produced less apoB.
E, apoB concentration in plasma was determined by Western blot analysis.
However, the double-stranded agent according to an embodiment achieved the significant inhibition of ApoB mRNA.
Concentrations of apo ( a ) and apoB in the transgenic rabbits were evaluated by ELISA.
Pharmacological examples . Quantification of the secretion of ApoB.
PPC significantly reduced oxidation of apoB lipoprotein, while niacin did not.
In the case of LDL, the major protein is ApoB.
ApoB mRNA expression was measured from mouse livers as discussed with respect to Figure 13.
The data confirm that compound A inhibits the secretion of TG-rich lipoproteins that contain apoB.
ApoB levels were reduced somewhat in both groups, however, these reductions are not statistically significant.
We also demonstrated that LDLR and apoB interact with GLG1.
