Examples of 'apremilast' in a sentence
Meaning of "apremilast"
Apremilast is an adjective related to a medication used to treat certain skin conditions and arthritis
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- A thalidomide analogue being developed to treat inflammatory diseases.
How to use "apremilast" in a sentence
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apremilast
Otezla contains the active substance apremilast.
Apremilast was studied in young and elderly healthy subjects.
Methods for the treatment of obesity using apremilast.
Apremilast is not an approved product for any indication.
The active substance is apremilast.
Apremilast is contraindicated during pregnancy.
There was no clinically meaningful interaction between ketoconazole and apremilast.
Apremilast may also be used.
There are limited data about the use of apremilast in pregnant women.
Apremilast has no influence on the ability to drive and use machines.
There was no pharmacokinetic interaction between apremilast and methotrexate in psoriatic arthritis patients.
Apremilast is not genotoxic.
The above data indicate that apremilast treatment improves liver function.
Apremilast is taken by mouth.
Duration of placebo treatment in the withdrawal phase is excluded from apremilast exposure.
See also
Apremilast is a phthalimide derivative.
One or more second active agents can be used in the invention together with apremilast.
Apremilast for the treatment of a liver disease or a liver function abnormality.
The adverse drug reactions were determined based on data from the apremilast clinical development programme.
Apremilast has not been studied for use during breastfeeding in humans.
Successful treatment of acrodermatitis continua of Hallopeau with apremilast.
Apremilast is associated with an increased risk of psychiatric disorders such as insomnia and depression.
Apart from hypersensitivity to the drug, there are no current contraindications for apremilast.
Apremilast demonstrated significant improvement in the primary endpoint and major secondary endpoint in the study.
Worsening depression, suicidal thoughts, and other mood changes may occur with apremilast.
Apremilast may also be used to alleviate adverse effects associated with some second active agents.
Further improvements in nail psoriasis were observed at Week 32 in patients continuously treated with apremilast.
The safety of apremilast was not evaluated in PsA or PSOR patients with hepatic impairment.
Human plasma protein binding of apremilast is approximately 68.
Apremilast can be co-administered with methotrexate.
Phosphodiesterase 4 inhibitors, such as apremilast.
Thus, a preparation of apremilast will inherently contain small amounts of deuterated isotopologues.
Hypersensitivity reactions were uncommonly observed in apremilast clinical studies see section 4.3.
Apremilast is, however, believed to work through a different mechanism and therefore will be discussed separately.
A total of 0.1 % of patients treated with apremilast discontinued due to adverse reaction of weight decreased.
Apremilast also significantly improved several measures of disease activity and quality of life at week 12.
Suitable examples for immunomodulatory agents ( IMIDs ) comprise thalidomide, lenalidomide, pomalidomide and apremilast.
Apremilast can be coadministered with a potent CYP3A4 inhibitor such as ketoconazole.
Long-term experience in open-label extension studies with apremilast was generally comparable to the 52-week studies.
Apremilast is not approved for the treatment of patients with Behçet 's disease in any country.
The major circulating inactive metabolite is the glucuronide conjugate of O-demethylated apremilast M12.
Apremilast has the following structure,.
Each film-coated tablet contains 10 mg of apremilast.
In a specific method, apremilast may be prepared, for example, by the following process.
Otezla 30 mg tablets apremilast.
Apremilast ( Otezla ) is currently the only FDA-approved small molecule medication on the market.
The same procedure is followed for apremilast and the positive control, 7-ethoxycoumarin ( 1 µM ).
Apremilast may be prepared according to methods disclosed in U.S. Patent Nos.
More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogues of apremilast.
Apremilast was detected in milk of lactating mice see section 5.3.
