Examples of 'arginase' in a sentence
Meaning of "arginase"
Arginase (noun): An enzyme that catalyzes the hydrolysis of arginine to urea and ornithine, with a wide range of biological functions
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- An enzyme that catalyses the hydrolysis of arginine to form urea and ornithine
How to use "arginase" in a sentence
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arginase
Arginase belong to the ureohydrolase family of enzymes.
The most preferred arginase inhibitor is norNOHA.
Arginase inhibitors and their therapeutic applications.
It is characterized by lowered activity of arginase in hepatic cells.
Arginase inhibitors and methods of use.
The use of an inhibitor of arginase for reducing hair growth.
Arginase catalyzes the hydrolysis of arginine to ornithine and urea.
Norvaline is an arginase inhibitor.
Arginase deficiency results in severe neurologic deterioration over time.
It works as an arginase inhibitor.
Arginase is a cytosolic enzyme which converts arginine to ornithine and urea.
Many compounds from natural products has been reported as inhibitors of arginase i.
It is bound to arginase of the liver and activates many enzymes.
Fractions were collected and assayed for amidinohydrolase and arginase activity.
Arginase inhibitors as therapeutics.
See also
We demonstrate that cAMP induces arginase polynucleotide and polypeptides levels in neurons.
Arginase enzymatic assays are well known to those of skill in the art.
Decreased arginine concentrations and synthesis of ornithine are indicative for arginase activity.
Arginase is known.
Methods for isolation of pegylated arginase based on temporary disruption of polymerization are also disclosed.
The aim was to compensate the metabolic and enzymatic deficiencies connected with endogenous arginase deficiency.
All of the above arginase variants are contemplated as useful for human therapy.
Long serum persistence improves the use of Arginase as a therapeutic.
It appears that arginase isoforms may play distinct but overlapping functional roles.
Experiments to identify compounds suitable for arginase inhibition are well known in the art.
Correlations between arginase activity and polyamine synthesis also been observed in kidney and intestine.
In certain aspects of the invention, methods and compositions related to pegylated arginase are disclosed.
Arginase II protein localization data is not available.
In some embodiments, the arginase contains a substitution.
Arginase I and II are induced in murine macrophage cell lines by cAMP.
Examples for suitable arginase inhibitors are but are not limited to,.
Arginase deficiency, unlike other urea cycle disorders, does not entirely prevent ureagenesis.
This peak also exhibited arginase activity, although only weakly.
The arginase inhibitor is however combined with suitable non-active additives in a prophylactic formulation.
In yet other embodiments, the arginase lacks a portion of the wild-type sequence.
Alternatively, a ribozyme specific for the mRNA of the macrophage form of arginase could be employed.
An adenovirus lacking arginase I and including GFP cDNA was made to use as a control.
What L-norvaline does is it is an arginase inhibitor.
In principle, any arginase inhibitor may be used according to the invention.
The composition for use according to claim 1 wherein said arginase is pegylated recombinant human arginase.
To overexpress arginase in a neuron, we used adenoviral-mediated gene transfer techniques.
Unlike L-arginine, it bypasses hepatic metabolism and is not a substrate of the arginase enzymes.
There are several arginase isozymes that differ in catalytic, molecular and immunological properties.
In other embodiments, the amino acid sequence comprises a truncated Arginase I or Arginase II sequence.
Preferably, the arginase inhibitor is used as the only active ingredient in the medicament.
In argininemia ( ARG ), the enzyme arginase is not working correctly.
OTC and arginase activities were suppressed in urea-treated tissues.
The transformation of ( C ) to proclavaminic acid could be mediated by an arginase - type enzyme.
A causal relationship between arginase activity and polyamine synthesis has not, however, been established.
In other embodiments, the amino acid sequence of human Arginase II comprises SEQ ID NO, 2.
