Examples of 'atropisomers' in a sentence
Meaning of "atropisomers"
Atropisomers are a type of stereoisomers that result from hindered rotation around a single bond in a molecule, leading to distinct spatial arrangements
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- plural of atropisomer
How to use "atropisomers" in a sentence
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atropisomers
Atropisomers are enantiomers without a single asymmetric atom.
The invention includes atropisomers and rotational isomers.
Atropisomers of the compounds can furthermore occur.
Certain compounds of the invention can exist as atropisomers.
The ratio of atropisomers at equilibrium may not be unity.
The compound described herein may also exist as atropisomers.
These atropisomers can be separated.
Methods for the separation of atropisomers are known in the art.
A suitable elution solvent is used to obtain separation of the atropisomers.
Atropisomers are conformational isomers which can be separated due to restricted rotation.
Some compounds of the present invention may exist as atropisomers.
The present invention also includes atropisomers of the present invention.
The compounds disclosed herein may exist as a mixture of atropisomers.
Separation of atropisomers is possible by chiral resolution methods such as selective crystallization.
The invention encompasses the racemic and the resolved atropisomers.
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In that case mixtures of atropisomers may be separated into single isomers.
Atropisomers may be separated by the methods well known in the art.
The present embodiments also include atropisomers of the compounds described herein.
Atropisomers refer to compounds that can be separated into rotationally restricted isomers.
The present invention also includes the preparation of atropisomers of the present invention.
Also atropisomers may occur as a result of restricted rotation about a single bond.
The phase diagram between the racemic composition of two couples of atropisomers has been defined.
Atropisomers are distinguished from enantiomers in that atropisomers do not possess a single asymmetric atom.
Compounds of the invention may also possess axial chirality which may result in atropisomers.
Atropisomers may have a sufficiently high rotational barrier to be conformationally stable at a temperature around rt.
The synthetic examples provided herein note where such mixtures of atropisomers have been observed.
Atropisomers refer to compounds of the invention that can be separated into rotationally restricted isomers.
It also shows that the more polar atropisomers have higher extinction coefficient in the infrared.
Mixture was then cooled and purified by prep HPLC to afford two atropisomers.
Separating the atropisomers of by HPLC to obtain the atropisomers.
Collection and concentration of the eluent from the individual atropisomers will afford the pure atropisomers.
The atropisomers of the compounds may be isolated using chiral LC.
This invention relates to those stereoisomers of compounds of the formula I that are atropisomers.
The two atropisomers of the title compound may be isolated using chiral LC.
The compounds of Formula I and salts thereof are intended to encompass any such atropisomers.
Atropisomers refer to compounds of formula I that can be separated into rotationally restricted isomers.
Furthermore, the present invention includes atropisomers.
All atropisomers of a structure are intended, unless the specific atropisomer is specifically indicated.
Furthermore, compounds referred to herein may exist as atropisomers.
When known, the resolved atropisomers were named using the helical nomenclature.
The various stereoisomers include enantiomers, diastereomers and atropisomers.
Atropisomers refer to compounds of formula 11 that can be separated into rotationally restricted isomers.
The various stereoisomers include enantiomer, diastereomers and atropisomers.
Atropisomers may he equilibrated thermally, and the interconversion barrier may be measured kinetically.
In certain embodiments, the compounds disclosed herein exist as a mixture of atropisomers.
All atropisomers and their mixtures, including the racemic mixtures, are embraced by the invention.
Compounds of the present disclosure include separable rotational isomers, or atropisomers.
The absolute spatial configurations of the atropisomers can be determined by single crystal x-ray crystallography.
The compounds of this invention comprise both mixtures of, and individual, atropisomers.
Where individual atropisomers have been isolatable, distinct chemical and biological properties have been observed.
