Examples of 'azetidine' in a sentence
Meaning of "azetidine"
azetidine: a heterocyclic compound containing a nitrogen atom in a four-membered ring structure
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- A saturated heterocycle containing three carbon atoms and one nitrogen atom
How to use "azetidine" in a sentence
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azetidine
A cyclobutane ring or an azetidine ring is more preferred.
Azetidine derivative for the treatment of peripheral neuropathies.
Preferred heterocycloalkyl group is an azetidine group.
Azetidine derivatives useful as modulators of cortical cathecolaminergic neurotransmission.
All other substituted benzyl azetidine compounds are made analogously.
Azetidine is a heterocyclic organic compound.
The intermediate crude azetidine was then acylated without purification.
The compounds of interest are spirocyclic isoxazoline derivatives with an azetidine moiety.
Martens and colleagues have used azetidine alcohols as ligands for asymmetric zinc additions.
The oil consists of a mixture of diphenylmethane and the free azetidine.
Aziridine and azetidine rings react with carboxylic groups in polymer systems on an aqueous basis.
Other prodrugs include alkyl derivatives and carbamate derivatives of the azetidine nitrogen.
Protecting the azetidine nitrogen with a nitrogen protecting group P to form a compound of the formula.
The present invention describes for the first time azetidine compounds as orexin antagonists.
Azetidine derivatives as FAAH inhibitors.
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The process according to claim 24 wherein the azetidine is prepared by the process comprising.
Azetidine and pyrrolidine are preferred, and azetidine is particularly preferred.
They may also be chosen from those containing oxirane, oxetane, azetidine or aziridine functional groups.
The azetidine derivatives are synthesized according to the following general methods,.
Prepare the following compounds essentially by the method of Preparation 74 using the corresponding substituted azetidine.
When all starting azetidine alcohol was consumed, the reaction mixture was concentrated in vacuo.
Composition comprising a dopaminergic agonist and of one or more CB1 antagonist azetidine derivatives of formula I,.
The present invention provides azetidine derivatives, which are non-peptide antagonists of human orexin receptors.
Examples of heterocycles are piperidine, piperazine, thiomorpholine, morpholine, azetidine or oxetane.
Amide analogs of the azetidine ring can be prepared as shown in Scheme 6.
Derivative 4 can be obtained by reacting the mesylate 2 with the azetidine 3.
The N-substituted azetidine derivatives of the present invention are ERa antagonists.
Removal of the benzhydryl protecting group with chloroethyl-chloroformate provides the azetidine 24.
Sulfonamide anlogos of the azetidine ring can be prepared as shown in Scheme 7.
Examples of 4-membered heterocycloalkyl groups include, and are not limited to, azetidine and a beta lactam.
The azetidine 17 can be used to prepare derivative compounds demonstrated in CHART A.
The 2-position of the azetidine ring is a chiral center.
Examples of such heterocycloalkyl groups include piperazine, piperidine, morpholine, homomorpholine, thiomorpholine, pyrrolidine, and azetidine.
N-substituted azetidine derivatives.
A compound according to claim 35 wherein R4i is ortho to the azetidine ring.
Process for synthesizing azetidine derivatives represented by formula ( I ), comprising the steps of,.
Examples of saturated 4 - to 8-membered rings containing 1 to 3 heteroatoms include morpholine, piperidine and azetidine.
An N - substituted azetidine derivative according to any one of claims 1 to 3 for use in therapy.
An alternative way to prepare N-substituted azetidine compounds 15 is outlined in Scheme 3.
Formation of the azetidine ( V ) is achieved by reaction of ( IV ) with a suitable nitrogen deprotection agent.
In another embodiment, C3-7cycloheteroalkyl is azetidine or pyrrolidine.
Azetidine joined to the remainder of the molecule at the 1 - and 3-positions e . g.
The compound of formula ( I ″ ) is reacted with ethylamine, dimethylamine or azetidine.
Additional azetidine ( one drop ) was added and the mixture stirred for another 2 hours at 60 °C.
Halogen-metal exchange mediated addition of the bromophenyl azetidine C to the dihydrofuranone 3 affords the 2,3-dihydrofuran 4.
In some embodiments, R10 is an optionally substituted azetidine.
Non-limiting representative examples include, morpholine, piperidine, pyrrolidine, piperazine, azetidine and N-methyl-piperazine.
Subsequent deprotection under catalytic hydrogenation ( Scheme 3, Step B ) may yield the desired substituted azetidine ( compound 12 ).
Scheme 5a describes the preparation of the 2,3-dihydrofuran compounds from the bromophenyl azetidine C and the dihydrofuranone 3.
In one embodiment, R1 and R2, together with the amide nitrogen, form an azetidine ring.
