Examples of 'backbone modification' in a sentence
Meaning of "backbone modification"
backbone modification: In genetics and biology, this term refers to the alteration or change in the structure of the backbone of a molecule, such as DNA or protein. It is often used to describe the process of modifying the core or fundamental part of a molecular structure
How to use "backbone modification" in a sentence
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backbone modification
One type of modified backbone is a phosphate backbone modification.
The phosphate backbone modification may be a phosphorothioate or phosphorodithioate modification.
Comprises at least one phosphorothioate or phosphorodithioate backbone modification.
The backbone modification may be any type of modification that forms a chiral center.
In some embodiments the modified backbone is a phosphate backbone modification.
Much like the aliphatic backbone modification this can negatively impact coating performance.
Preferred stabilized oligonucleotides of the present invention comprise a phosphate backbone modification.
An S following a nucleotide denotes a backbone modification consisting of a phosphorothioate internucleoside linkage.
The immunostimulatory oligonucleotides of the invention comprise at least one phosphorothioate backbone modification.
An S following a nucleotide denotes a backbone modification consisting of a phosphorothioate intemucleoside linkage.
In some embodiments, the polynucleotide oligomer comprises a backbone modification.
In some cases, the backbone modification is a phosphothioate linkage.
Amino acid side chain modification or substitution ; or polypeptide backbone modification.
Includes a phosphate backbone modification which is a phosphorothioate or phosphorodithioate modification ; or.
Alternatively, or in addition, the binding region may be subjected to backbone modification.
See also
For example, aliphatic backbone modification can be used to impart flexibility in these systems.
Specifically, the oligonucleotides comprise at least one phosphorothioate backbone modification.
The method described in paragraph 59 wherein the backbone modification is a phosphorothioate backbone modification.
In an additional embodiment, the dsRNA has a phosphonate, a phosphorothioate or a phosphotriesterphosphate backbone modification.
A composition according to claim 10, wherein the phosphate backbone modification is phosphorothioate or phosphorodithioate.
A phosphate backbone modification selected from the group consisting of a phosphonate, a phosphorothioate and a phosphotriester.
For instance, in some embodiments at least one nucleotide has a phosphate backbone modification.
The oligonucleotide according to claim 2, wherein the phosphate backbone modification is a phosphorothioate or phosphorodithioate modification.
The use according to claim 1, wherein at least one nucleotide has a phosphate backbone modification.
The use according to claim 4, wherein the phosphate backbone modification is a phosphorothioate or phosphorodithioate modification.
In a further example, a further modified polynucleotide oligomer comprises a backbone modification and a label.
In this case, the backbone modification renders the substrate reagent resistant to restriction endonuclease cleavage.
In a particular embodiment of the present invention, the backbone modification is a modified sugar phosphate backbone.
For example, a further modified polynucleotide oligomer comprises a sugar modification and a backbone modification.
Furthermore, the phosphate backbone modification may be a 3 ' inter - nucleotide linkage modification.
Prolonged immunostimulation can be obtained using stabilized oligonucleotides, where the oligonucleotide incorporates a phosphate backbone modification.
The 5 ' - oligonucleotide contains a backbone modification such as the mentioned examples at its 3 ' - end.
In some cases, the ASO comprises one or more backbone modification.
CCGAGCCGAAGCUGCC SEQ ID NO, 88 ; wherein the ORN optionally includes at least one backbone modification.
The cleavable linker for this example is a 3 ' OP-N 5 ' substrate backbone modification.
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