Examples of 'betulinic acid' in a sentence
Meaning of "betulinic acid"
betulinic acid: Betulinic acid is a naturally occurring compound found in plants like white birch trees, valued for its potential medicinal properties, such as anti-inflammatory, antiviral, and anticancer effects
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- A naturally-occurring pentacyclic triterpenoid with antiretroviral, antimalarial and antiinflammatory properties
How to use "betulinic acid" in a sentence
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betulinic acid
The betulonic acid is reduced to betulinic acid.
Betulinic acid is a pentacyclic triterpene.
The active compound is a derivative of betulinic acid.
Betulinic acid ethylester precipitated and was recrystallized from ethanol.
Mitochondria without addition of betulinic acid bad no effect on nuclei.
Betulinic acid also does not suffer from the drawback of scarcity.
Synthetic access to the compounds begins with betulin or betulinic acid.
Betulinic acid has a wide range of biological effects including potent antitumor activity.
A mixed melting point range with a known sample of betulinic acid was not depressed.
Betulinic acid is a common triterpene available from many species throughout the plant kingdom.
The initial study investigated the activity of betulinic acid against unestablished tumors.
Especially betulinic acid and betulonic acid seem to posses high bioactivities in several applications.
The growth of all the cell lines was inhibited significantly by treatment with betulinic acid.
These results suggest that betulinic acid could exert potent antitumor activity in vivo.
Betulinic acid has shown a strong selective antitumor activity against melanoma by induction of apoptosis.
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Visual inspection of melanoma cells treated with betulinic acid revealed numerous surface blebs.
Use of betulinic acid for the manufacture of a medicament for stimulating collagen synthesis in skin.
Rich in Betulin and betulinic acid.
The effectiveness of betulinic acid against melanoma cancer cells was also tested using athymic mice.
Such clearly defined cell-type specificity demonstrated by betulinic acid.
Betulinic acid was coprecipitated with PVP to increase solubility and bioavailability.
Next, in vivo testing of betulinic acid was performed on established melanomas.
Betulinic acid and its derivatives interfere with Selectin binding.
The composition of claim 1 wherein the source of betulinic acid is a plant extract.
Betulinic acid Moronic acid Oleanolic acid.
These compounds showed considerably improved anti-invasive effects compared to betulinic acid.
Betulinic acid has the following formula,.
In one preferred embodiment, at least one betulinic acid derivative comprises a single pharmaceutical composition.
As such, this method is not attractive for the commercial scale production of betulinic acid.
However, instead of betulinic acid ethylester betulin has been used.
Triterpenes, specifically Betulin and Betulinic acid.
Fig . 7 shows that betulinic acid directly triggers mitochondrial permeability transition.
Thus, there exists a need for improved methods for preparing betulinic acid and synthetic precursors thereof.
This indicates that betulinic acid triggers the mitochondrial release of soluble apoptogenic factor ( s ).
Amino compound 9 exhibited an improved cytotoxicity compared to betulinic acid 10.
Therefore, the mode of action by which betulinic acid mediates the melanoma-specific effect was investigated.
Fig . 2A shows caspase activity as affected by betulinic acid.
Previously, betulinic acid and platanic acid were isolated as anti-HIV principles from Syzigium claviflorum.
Example 19 A suitable formulation of betulinic acid derivatives was prepared as follows.
Betulinic acid was found to inhibit in vitro growth of MEL-2 cells.
The anti-inflammatory properties of betulin, betulinic acid and 16 semisynthetic betulin derivatives were also investigated.
In table 2 are presented results of oxidation of betulinic aldehyde to betulinic acid ( reaction II ).
Modified c-3 betulinic acid derivatives as hiv maturation inhibitors.
SHEP cells treated with 10 µg / ml betulinic acid for indicated times.
In addition, betulinic acid has been reported to have an anti-HIV activity.
SH-EP neuroblastoma cells were treated with 10 µg / ml betulinic acid for the indicated times.
Fig . 4A-B show betulinic acid induced disturbance of mitochondrial function.
Compounds 2, 8, and 13 showed a decrease in selective cytotoxicity compared to betulinic acid.
Fig . 6A-B show the effect of betulinic acid on drug resistant cells.
The cyclopeptide alkaloid neutral is known as discarene c ( 63 ) and triterpenoid is known as betulinic acid 69.
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