Examples of 'bi-specific' in a sentence
Meaning of "bi-specific"
bi-specific: referring to something that is able to interact with two specific targets or molecules. In biology, this may refer to antibodies that can bind to two different antigens
How to use "bi-specific" in a sentence
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bi-specific
In one embodiment the construct is a bi-specific antibody.
Hemlibra is the first bi-specific monoclonal antibody to be approved.
Bi-specific mAbs bind at least two different antigens.
In particular the antibody of the invention is a bi-specific antibody.
Such bi-specific molecules can be created in two different ways.
In one embodiment of the present invention, the antibody is a bi-specific antibody.
Variations on the bi-specific antibody format described above are contemplated.
The immune cell composition of claim 6 wherein the agent is a bi-specific antibody.
Traditional bi-specific or multi-specific antibodies can be difficult to manufacture.
In certain embodiments, the antibodies of the present invention may be bi-specific antibodies.
In one embodiment the bi-specific molecules according to the disclosure are humanised.
Components may also be linked with the use of bi-specific linker molecules.
Bi-specific antibodies may also be obtained when two whole antibodies are attached.
In a second embodiment, a physiological solution of the bi-specific antibody is administered, preferably intravenously or intraarterially.
The bi-specific molecule may comprise a signal peptide to aid in its production.
See also
A variety of recombinant methods can be used to produce bi-specific antibodies and antibody fragments.
For example, the bi-specific proteins can enhance or maintain the viability of a cell.
Such information may be used to determine the effective dose of the bi-specific fusión protein.
In some embodiments, the bi-specific protein further comprises a peptide half life modulator.
The present disclosure relates to compositions and methods of treatment relating to recombinant bi-specific antibodies.
The bi-specific antibody may be recharged in vivo after cell-specific delivery of the payload.
The treatment dosage was increased to daily bi-specific antibody injection for a total of 6 consecutive days.
The bi-specific binding agents provided herein are not necessarily limited to two binding specificities.
In accordance with one embodiment, the bi-specific antibody comprises monoclonal antibodies or antibody fragments.
Bi-specific antibodies can equally be produced by chemically coupling two antibodies having the desired specificity.
In accordance with another embodiment, the bi-specific antibody comprises humanized antibodies or antibody fragments.
The bi-specific molecule of the invention may comprise a signal peptide to aid in its production.
The present disclosure relates to the first bi-specific antibody construct derived from a TCR-like mAb.
A bi-specific antibody molecule consisting of three polypeptides ;.
The present disclosure relates to bi-specific antibodies derived from a TCRm mAb, designated ESK.
In certain embodiments, the antibody is a bi-specific antibody.
In one example the bi-specific antibody is used as a payload delivery vehicle for imaging reagents.
So we are interested in producing the VSTs bi-specific to ADV and EBV.
A method for producing bi-specific antibody fragments is described by Holliger et al.
Preferably the Fab-dsscFv fusión protein is bi-specific.
Exemplary bi-specific Abs may bind to two different epitopes on a given WUP.
In certain embodiments, a bi-specific antibody may be used.
Exemplary bi-specific Abs can bind to two different epitopes on a given TCA.
The multi-specific binding substance may be bi-specific.
It may be a bi-specific antibody or antibody fragment ( as discussed ).
In particular, the present invention is related to bi-specific antibodies.
In some embodiments, the bi-specific proteins can modulate apoptosis.
The antibody may be monospecific or multi-specific including bi-specific.
Preferably, said bi-specific antibodies are humanized and chimeric antibodies.
An analog may be a non-peptide analog of a bi-specific antibody described herein.
The bi-specific molecule may have the general formula,.
In specific embodiments, scFvs include bi-specific scFvs and humanized scFvs.
Bi-specific fusión proteins.
In specific embodiments, single-chain antibodies can also be bi-specific and / or humanised.
The bi-specific antibodies were given every day for a total of 5 days.
