Examples of 'bicyclic nucleoside' in a sentence
Meaning of "bicyclic nucleoside"
bicyclic nucleoside: A bicyclic nucleoside is a chemical compound consisting of a nucleoside (a nitrogenous base linked to a sugar molecule) with a bicyclic structure. These molecules have two connected rings in their structure and are commonly found in pharmaceuticals and biochemistry for various applications
How to use "bicyclic nucleoside" in a sentence
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bicyclic nucleoside
A bicyclic nucleoside may have a modified or unmodified nucleobase.
In certain embodiments, a modified nucleoside is a bicyclic nucleoside.
Wherein independently for each bicyclic nucleoside having Formula III, Bx is a heterocyclic base moiety ;.
In certain embodiments, each nucleoside of the 5 ′ - wing of a gapmer is a bicyclic nucleoside.
In some embodiments, the bicyclic nucleoside is defined by Formula VI, wherein,.
In certain embodiments, the 5 ′ - wing of a gapmer comprises at least one bicyclic nucleoside.
The bicyclic nucleoside of claim 1 having Formula II,.
Oligomeric compounds are also provided having at least one bicyclic nucleoside having formula I, wherein,.
A bicyclic nucleoside having Formula II, wherein,.
Wherein independently for each of said at least one bicyclic nucleoside having Formula III,.
The bicyclic nucleoside of any one of claims 1 to 8 having Formula II,.
An oligomeric compound comprising at least one bicyclic nucleoside having Formula III,.
In certain embodiments, bicyclic nucleoside having Formula IV, wherein, Bx is a heterocyclic base moiety ;.
Base-induced ring closure afforded the bicyclic nucleoside derivative 8.
In certain embodiments, bicyclic nucleoside having Formula III, wherein, Bx is a heterocyclic base moiety ;.
See also
A subscript " l " indicates an INA bicyclic nucleoside.
In some embodiments, bicyclic nucleoside is defined by Formula V, wherein,.
The oligomeric compound of claim 16 wherein each bicyclic nucleoside has Formula IV,.
In some embodiments, bicyclic nucleoside is defined by Formula III, wherein,.
Unless otherwise indicated, a 2 ′ - substituted nucleoside is not a bicyclic nucleoside.
In certain embodiments, bicyclic nucleoside having Formula VI, wherein,.
The bicyclic nucleoside of claim 1 wherein each of T1 and T2 is a hydroxyl protecting group.
In certain embodiments, bicyclic nucleoside having Formula IV, wherein,.
The bicyclic nucleoside of any one of claims 1 or 3 wherein q1 and q2 are each methyl.
In certain embodiments, bicyclic nucleoside having Formula V, wherein,.
The bicyclic nucleoside of claim 1 wherein at least one of q1 and q2 is substituted C1-C6 alkyl.
The bicyclic nucleoside of claim 5 wherein q3 and q4 are each H.
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Examples of using Nucleoside
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Nucleoside analogue reverse transcriptase inhibitors NRTIs
Cladribine is a purine nucleoside analogue acting as an antimetabolite
Nucleoside analogues are also used as antiviral agents
Examples of using Bicyclic
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Bicyclic alkenes include norbornene and norbornadiene
Norbornadiene is a bicyclic hydrocarbon and an organic compound
Bicyclic and tricyclic mesogenic compounds are preferred
