Examples of 'brachyury' in a sentence
Meaning of "brachyury"
Brachyury is a gene that plays a crucial role in the formation of the notochord in vertebrates
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- The presence of an abnormally short tail in some animals as a result of a genetic mutation.
How to use "brachyury" in a sentence
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brachyury
Brachyury is overexpressed in a number of tumor types.
Mesoderm cells may express various markers including expression of the transcription factor brachyury.
Brachyury polypeptides are also of use in the methods disclosed herein.
The brown signal represents staining for Brachyury.
Brachyury expression increased progressively over the course of the experiment.
Immunohistochemical detection of Brachyury in primary breast carcinoma and metastatic tissues.
Differentiated cells show a correlation of EGFP fluorescence with endogenous brachyury gene expression.
Expression of Brachyury mRNA in breast carcinoma tissues.
Metastatic lesions from additional patients were also analyzed for Brachyury expression by immunohistochemistry.
The Brachyury protein or polypeptide can be administered in a liposome.
Adjacent and distal breast tissues in the samples were negative for Brachyury expression.
The isolated Brachyury protein or polypeptide may be included in a fusión protein.
These vectors include a polynucleotide that encodes a Brachyury protein or Brachyury polypeptide.
Thus a Brachyury specific binding agent is an agent that binds substantially to a Brachyury protein.
SPARC and TM are expressed in parietal endoderm and Brachyury is expressed in early mesoderm.
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Effect of Brachyury expression on stem cell marker expression and mammosphere growth of tumor cells.
Immunogenicity of Brachyury.
A polynucleotide sequence encoding a Brachyury protein or polypeptide can be operatively linked to expression control sequences.
In one embodiment, the protein is a Brachyury protein.
A polypeptide that is heterologous to Brachyury originates from a nucleic acid that does not encode Brachyury.
The Brachyury protein can also be administered with agents that promote dendritic cell maturation.
Furthermore, germ line duplication of brachyury confers major susceptibility to chordoma.
These Brachyury proteins can also be used to induce a Brachyury specific T cell response.
In one aspect of the invention, the antigen is human Brachyury.
The cancer can express Brachyury or have the potential to express Brachyury.
In several examples, the subject has a cancer that expresses Brachyury.
The five fold increase of brachyury by day 5 indicated the cells had differentiated into mesoderm.
Lacks of expression of one or more of the mesodermal markers Brachyury and Bmpr2 ;.
Moreover, only the Brachyury protein or polypeptide may be utilized.
Thus, a second heterologous moiety is non-covalently linked to the Brachyury protein or polypeptide.
The Brachyury protein and / or Brachyury polypeptide may be included in a liposome.
A pharmaceutical composition including a Brachyury protein and / or Brachyury polypeptide is thus provided.
There are also disclosed cell cultures having increased expression of brachyury and FGF4 mRNA.
When bound to a carrier, the bound Brachyury protein or Brachyury polypeptide becomes more immunogenic.
These vectors can all be used, without limitation, for the expression of a Brachyury protein.
Adjuvants can also be administered with the Brachyury protein and / or Brachyury polypeptide.
There are now eight T-box genes in the mouse not including Brachyury.
Peptide Modifications, Brachyury proteins include synthetic embodiments of peptides described herein.
Replicons comprise RNA, including sequences encoding Brachyury protein, and are encapsidated.
These compositions also can be used to induce a CD8 + T cell response to Brachyury.
These polypeptides can be used to induce a Brachyury specific CD4 + T cell response.
Murine Brachyury is approximately 91 % identical to human Brachyury at the amino acid level.
In one aspect, the antigen is Brachyury.
An exemplary assay for measuring Brachyury specific CD4 + T cells is disclosed in the examples below.
Fig . 2c shows little expression of mesoderm marker Brachyury in aggregates.
The Brachyury proteins may not include the first amino acid of SEQ ID NO, 1 ( methionine ).
SEQ ID NO, 3 is an amino acid sequence of a murine Brachyury protein.
Early mesoderm expresses the genes Brachyury and MOX1 while nascent neuro-ectoderm expresses SOX1 and ZIC1.
SEQ ID NO, 1 is an amino acid sequence of a human Brachyury protein.
As shown in Figure 5A, brachyury mRNA expression peaked at about 24 hours.
