Examples of 'c-met' in a sentence
Meaning of "c-met"
C-met is a verb used in biology to describe the process of a receptor tyrosine kinase
How to use "c-met" in a sentence
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c-met
Many c-Met inhibitors are currently in clinical trials.
Various amidophenoxyheteroaryl c-Met inhibitors have been reported.
Compounds of the current invention are inhibitors of c-Met.
A monomeric c-Met form was used as a positive control.
This receptor is a protein produced by the c-Met oncogene.
Additionally c-met has been linked to leukemia.
Also provided is a method of inhibiting the activity of c-Met.
Treating a c-met associated cancer in a mammal.
The tumor may be determined to comprise hyperstabilized c-met.
The c-Met receptor also is a receptor tyrosine kinase.
Compounds of the present invention were found to be inhibitors of c-Met.
The c-Met is also implicated in glioblastoma.
A method of inhibiting the activity of c-Met is disclosed herein.
Distribution of c-Met protein in the adult rat brain.
Also disclosed is a method of inhibiting the activity of c-Met.
See also
Preferred such c-Met inhibitors are synthetic.
The compounds of the invention are endowed with c-Met inhibitory activity.
Inhibition of hyperstabilized c-met activity provides numerous therapeutic advantages.
The c-Met receptor has been shown to be expressed in a number of human cancers.
In addition, various concentrations of c-Met inhibitors were added to this solution.
Hence c-Met had been selected as a target for cancer therapy.
The compounds of the invention have c-Met inhibitory activity.
Agents targeting c-Met signaling pathway are now under clinical investigation.
The loading controls were developed with c-Met respectively tubulin antibodies.
The compounds exemplified herein have been assayed and inhibit c-Met.
Often, oncogenic mutations of c-Met cause a resistance to small molecule inhibitors.
It is disclosed that said antibody is capable of inhibiting the c-Met dimerization.
For example, a function of c-Met includes phosphorylation of downstream target proteins.
The compounds of the present invention can act as inhibitors of c-Met.
Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer.
More particularly, these antibodies are capable of inhibiting the c-Met dimerization.
Preliminary clinical results of several c-Met antagonists are now under clinical investigation.
These abstracts and posters disclose no data relating to c-Met internalization.
The list of neoplasms in which c-Met overexpression has been detected is growing relentlessly.
In some embodiments, a medicament thus prepared can be used as an inhibitor of c-Met.
The protective effect of the activated c-Met on cell survival has been documented.
In some embodiments, the condition is a cancer mediated at least in part by c-Met.
The nexus between c-Met and colorectal cancer has also been established.
The present invention is applicable to antibodies that specifically bind c-met.
The activation of c-Met in normal cells is a transient event and is tightly regulated.
The present invention is directed to novel compounds having c-Met inhibitory activity.
Exemplary embodiments of the c-Met antibodies are now further described by reference to structural characteristics.
Also described herein are methods for screening for or identifying a c-met antagonist.
Optionally, a nucleic acid encodes a c-met antagonist which is or comprises an antibody or fragment thereof.
In another example, an antagonist targets a linked toxin to a cell expressing hyperstabilized c-met.
The particular epitopes to which these c-Met antibodies bind is not provided.
Alternate in vitro assays quantitate the ability of the inhibitor to bind to c-Met.
In one embodiment, an antagonist antibody of the invention disrupts c-met dimerization comprising homodimerization.
In another embodiment, the substance is capable of specific binding to the hyperstabilized c-met.
Compounds of the present invention showed inhibition of c-Met kinase at doses less than 2 µM.
