Examples of 'calicheamicin' in a sentence
Meaning of "calicheamicin"
calicheamicin (noun): A highly potent cytotoxic compound derived from bacteria, known for its antitumor properties and used in the development of certain cancer treatments
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- Any of a class of enediyne antibiotics derived from the bacterium Micromonospora echinospora, extremely toxic to all living cells and used in targeted therapy against cancer.
How to use "calicheamicin" in a sentence
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calicheamicin
Crosshairs indicate the sensitivity to free calicheamicin.
Calicheamicin is another immunoconjugate of interest.
Intermediates and methods for synthesizing calicheamicin derivatives.
Is the concentration of calicheamicin given either as a pure substance or as a conjugate.
An antibody may be conjugated to one or more calicheamicin molecules.
A calicheamicin equivalent cal.
Processes for the convergent synthesis of calicheamicin derivatives.
The calicheamicin derivatives can in turn be conjugated to biomacromolecules such as monoclonal antibodies.
Another conjugate of interest comprises an antibody conjugated to one or more calicheamicin molecules.
Drugs such as doxorubicin and calicheamicin can be directly attached to monoclonal antibodies.
Another immunoconjugate of interest comprises an antibody conjugated to one or more calicheamicin molecules.
The calicheamicin hydrazide derivative is attached vía hydrazone formation to the monoclonal antibody.
The immunoconjugate may comprise an antibody conjugated to one or more calicheamicin molecules.
The serum concentrations of unconjugated calicheamicin derivatives are expected to be below the quantification limit.
Another immunoconjugate of interest comprises the glycoprotein conjugated to one or more calicheamicin molecules.
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A method of synthesizing a calicheamicin derivative of Formula VI wherein J is.
In other examples the immunoconjugate comprises an antibody conjugated to one or more calicheamicin molecules.
Thereby synthesizing a calicheamicin derivative of Formula VI.
This is consistent with the known induction of DNA breaks by calicheamicin.
Approximately 6 molecules of calicheamicin derivative are attached to each antibody molecule.
Field of the Invention The invention relates to synthesis of calicheamicin derivatives.
Finally, the calicheamicin derivative is to be purified after its formation.
Alternatively, the antagonist is conjugated to one or more calicheamicin molecules.
Toxins such as calicheamicin or a maytansinoid and analogs or derivatives thereof, are preferable.
Alternatively, the agent is conjugated to one or more calicheamicin molecules.
Toxins such as calicheamicin or a maylansinoid and analogs or derivatives thereof, are preferable.
Alternatively, the antibody variant is conjugated to one or more calicheamicin molecules.
Calicheamicin derivatives can, for example, be attached to lysine residues of the antibody.
Alternatively, the antibody may be conjugated to one or more calicheamicin molecules.
Conjugating the calicheamicin derivative of Formula VI resulting from step ( c ) to a monoclonal antibody.
Drug-loading assays do not differentiate between unconjugated and conjugated calicheamicin.
In vitro, N-acetyl gamma calicheamicin dimethyl hydrazide is primarily metabolised via nonenzymatic reduction.
A preferred cytotoxic agent is a toxin, preferably a small molecule toxin such as calicheamicin or a maytansinoid.
The calicheamicin then breaks up the leukaemia cells ' DNA, eventually killing the cells.
In other embodiments, the immunoconjugate comprises an antibody conjugated to one or more calicheamicin molecules.
The calicheamicin family of antibiotics are capable of producing doublestranded DNA breaks at sub-picomolar concentrations.
In a preferred embodiment, the cytotoxic drug is gamma calicheamicin or N-acetyl calicheamicin.
The calicheamicin family of antibiotics is capable of producing double-stranded DNA breaks at sub-picomolar concentrations.
A murine CTMO1 conjugate containing the same calicheamicin was also tested for comparison.
The same stereochemistry has been suggested for the Bergman product derived from calicheamicin Y ₁.
An example of a calicheamicin antibody conjugate is commercially available ( MylotargTm ; Wyeth-Ayerst ).
The anti-CD19 immunotherapy may be in conjunction with one or more calicheamicin molecules.
Purifying the calicheamicin derivative / carrier conjugate produced in step ( 1 ) to produce a monomeric calicheamicin derviative / carrier conjugate.
Preferably, the cytotoxic agent is a toxin selected from maytansinoid, ricin, saporin and calicheamicin.
An example of a calicheamicin antibody conjugate is commercially available ( Mylotarg ™ ; Wyeth ).
The anti-CD33 antibody in GO is coupled with calicheamicin through an acid-sensitive linker.
N-acetyl gamma calicheamicin DMH ( the released cytotoxin ) was found to be mutagenic and clastogenic.
For the preparation of conjugates of the calicheamicin family, see U.S. Pat.
The calicheamicin then breaks up the cells' DNA, eventually killing the cells.
In another embodiment of the method of synthesizing a calicheamicin derivative Formula VI, each R10 is hydrogen.
