Examples of 'calpain' in a sentence
Meaning of "calpain"
calpain (noun) - a family of calcium-dependent proteases involved in various cellular processes such as cell proliferation, differentiation, and apoptosis
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- Any of a family of enzymes that regulate calcium in the body.
How to use "calpain" in a sentence
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calpain
Other calpain inhibitors have also been studied.
This increase in calcium leads to activation of calpain.
Aggregin was hydrolyzed in vitro by calpain but not by thrombin.
This might be a consequence of the lethality of calpain.
Source of calpain was analyzed by immunohistochemistry.
The inhibitory activity against calpain was determined.
Calpain is also found in high concentration in corneal lens epithelium.
Functional consequences of a redox regulated activation of calpain in diabetes.
This suggests that activation of calpain is necessary for effective regeneration.
One is that it activates calcium dependent proteases such as calpain.
Recovering enzymatically active calpain from said cells.
Association of calpain inhibitors and reactive oxygen species trapping agents.
Carboxamide compounds and their use as calpain inhibitors.
No calpain expression was detected.
The compounds are useful as calpain inhibitors.
See also
Calpain inhibitors of the present invention can minimize the degeneration observed.
One hundred microliters of the calpain inhibitor are deposited in the wells.
Calpain has also been identified as a central mediator essential for parasitic activity.
Calcium channel blockers and calpain inhibitors have also been investigated.
This potentiation implies calcium deregulation seen by the cytosolic activation of calpain.
The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits.
The expression and recovery of recombinant enzymatically active calpain is specifically disclosed.
The involvement of calpain in HIV disorders has only recently been shown.
The present invention relates to a novel hydroxymorpholinone derivative having a calpain inhibitory activity.
The intracellular calcium activates the protease calpain which converts xanthine dehydrogenase to xanthine oxidase.
The ones that have been studied most seem to be caspase inhibitors and calpain inhibitors.
This proves the synergy between the calpain inhibitor and the reactive oxygen species trap.
The vectors of the present invention may also be administered in combination with calpain inhibitors.
It is known that calpain activates the EGF receptors as its substrate.
The above results clearly indicate that all compounds tested exhibited significant inhibition of calpain.
The enzyme calpain is commercially available and may be purchased from Sigma.
There is evidence that the activation of Calpain is an early event in cell death.
The activation of Calpain leads to the proteolysis of many proteins including spectrin.
Disclosure of the Invention The invention aims to provide a compound having a calpain inhibitory activity.
Calpain inhibitor I has been observed to increase the infectivity of cell lines to recombinant adenovirus.
It has additionally been found that calpain inhibitors show cytotoxic effects on tumor cells E.
Technical Field The present invention relates to a novel cyclic hemiacetal derivative having a calpain inhibitory activity.
Mechanism of calpain mediated dopamine loss in PD.
Open circles represent activity with calcium and calpain inhibitor I present.
Calpain inhibitor I can be used as a control for assaying inhibition of calpain.
The compounds of this invention are highly potent inhibitors of calpain and cathepsin B.
Samples without calpain inhibitor I present can be used as enzyme activity controls.
A method of preparing recombinant mammalian calpain comprising,.
Preferably, the calpain is recombinant enzymatically active human calpain.
A method for preparing recombinant mammalian calpain comprising,.
As such, finding and exploiting calpain inhibitors is an important area of research.
Therefore, a recombinant system for producing active calpain is needed.
Accordingly, a calpain inhibitor can be used as a therapeutic agent for fulminant hepatitis.
Well-known examples of cysteine proteases are papain and calpain.
The carboxamide compounds are inhibitors of calpain ( calcium dependent cysteine proteases ).
