Examples of 'cdks' in a sentence
Meaning of "cdks"
Cdks (noun): This term does not have a widely recognized definition in English. It may be a specific term related to a particular language, culture, or context
How to use "cdks" in a sentence
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cdks
Level of regulation of the activity of CDKs exists.
About a half dozen other CDKs were identified in humans.
Cdks regulate transitions between successive stages of the cell cycle.
Pharmacological inhibitors of CDKs thus constitute potential therapeutic molecules.
Proteins with no homology to the cyclin family can be direct activators of CDKs.
Inhibitors of CDKs may also have utility as antivirals.
The cyclins are the regulatory subunits that activate the catalytic CDKs.
Numerous viruses require CDKs for their replication process.
Monomeric CDKs are activated when they are associated with cyclins and thus have a kinase activity.
Some of the biochemical pathways in which CDKs play a key role have also been described.
The role of cdks in the regulation of cellular proliferation is thus well established.
MyoD is inhibited by cyclin dependent kinases CDKs.
Excess levels of cdks persist throughout the cell cycle.
CDKs are also known to play a role in apoptosis.
The selective inhibition of CDKs is therefore an object of the present invention.
See also
CDKs are proteins that control the cell cycle.
It competes for the ATP site of the CDKs.
Cyclins bind to CDKs and are activated during specific checkpoints of the cell cycle.
The mammalian cell cycle is governed by sequential activation of the Cdks.
CDKs are catalytically active only when bound to a regulatory cyclin.
Meiotic cell divisions are regulated by cyclins associated to their binding catalytic partners Cdks.
CDKs require for activation the association with a regulatory cyclin subunit.
It instead exhibited the sequence TQE resembling the THE sequence found in some Cdks.
CAK phosphorylates CDKs on the threonine residue to make the target enzyme totally active.
However, phosphorylation by plant CDKs remains to be demonstrated.
Cyclins bind to CDKs and this association is essential for CDK activity within the cell.
In addition, we describe the development of scoring functions tailored to cdks.
CDKs are composed of a catalytic CDK subunit and a regulatory cyclin subunit.
Wee1 kinase directly phosphorylates CDKs on the same residues.
Moreover, CDKs appear to be downstream of a number of oncogene signalling pathways.
The compound has revealed to be a potent ATP-competitive inhibitor of CDKs.
The CDKs have been implicated in cell proliferation disorders, particularly in cancer.
Most of them are targeting multiple CDKs, but some are targeting specific CDKs.
Although CDKs are the master regulators of mitotic entry, they do not act alone.
Other compounds that were shown to inhibit CDKs are staurosporine, fascaplysin and hymenialdisine.
The cdks themselves are regulated at many levels such as, for instance, binding to cyclins.
Several compounds that inhibit cdks have demonstrated preclinical anti-tumor activity.
Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases CDKs.
Thus, both the cyclins and cdks appear to be highly conserved protein families.
After the human genome project, a bunch of new CDKs and cyclins appeared.
Several compounds that inhibit cdks have demonstrated both preclinical and clinical anti-tumor activity.
However, exposure to flavopiridol or olomoucine which inhibit cdks prevented apoptosis in these cells.
To date, thirteen CDKs have been identified in humans Chen et al.
In addition, they described some of the biochemical signaling pathways that cdks play a key role.
CDKs are considered a potential target for anti-cancer medication.
Cyclins function as regulators of CDKs Cyclin-dependent kinase.
In animals CDKs are negatively regulated by two families of CDK inhibitors ( CKIs ).
D3-type cyclins typically have the ability to bind and activate plant CDKs and Rb.
CDKs regulate initiation, progression, and completion of the mammalian cell cycle.
Cyclin D3s typically have the ability to bind and activate plant CDKs and Rb.
