Examples of 'chain locus' in a sentence
Meaning of "chain locus"
chain locus: Refers to a concept in psychology related to the idea that individuals can control their reinforcement
How to use "chain locus" in a sentence
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chain locus
Deletion of the mouse λ light chain locus.
The human λ light chain locus is richly diverse.
The immunoglobulin locus is a heavy chain locus.
The mouse k light chain locus is strikingly different.
Deletion of the mouse k light chain locus.
The λ light chain locus may be deleted in part or completely.
The immunoglobulin locus may be a heavy chain locus.
A chain guide plate and a chain locus regulating means.
The transgenic animal may comprise a human k light chain locus.
The human heavy chain locus is the largest and most diverse.
For ligation into the humanized heavy chain locus.
The chain locus regulating means includes a pair of chain locus regulating members.
Optionally the genome is homozygous for said transgenic heavy chain locus.
The chain locus regulating means is slidably located at the rigid chain part.
The mouse may further comprise a disabled endogenous immunoglobulin light chain locus.
See also
A preferred strategy for disrupting the heavy chain locus is the elimination of the J region.
Interbreeding of offspring is performed to produce homozygotes lacking a functional endogenous heavy chain locus.
The targeting vectors for disrupting the heavy chain locus are illustrated in Fig.
The animal may be heterozygous or homozygous for a substantially inactivated endogenous λ light chain locus.
The primary strategy for disrupting the heavy chain locus is the elimination of the J region.
This example provides for the targeted knockout of the murine heavy chain locus.
The ES cell may further comprise a human heavy chain locus and a human k light chain locus.
The human VH domain is expressed from an endogenous immunoglobulin heavy chain locus.
Several mouse strains with silenced k I chain locus have been described.
Introduction of ten additional human Vx gene segments into a hybrid heavy chain locus.
Alternatively, the light chain locus may be the first.
This also directly influences the copy number of VH genes at the heavy chain locus.
In a specific aspect, the λ light chain locus is deleted in whole or in part.
The ES cell or progeny may comprises a substantially complete germline human λ light chain locus.
In a specific embodiment, the λ light chain locus is deleted in whole or in part.
In a specific embodiment, the immunoglobulin locus is a heavy chain locus.
Alternatively, the light chain locus may be the first to be inactivated.
The vector can be used for the expression of a heterologous heavy chain locus in rodents.
The human λ light chain locus may be a substantially full-length germline sequence.
PCR primer sets were designed to cover the Ig heavy chain locus of the mouse.
The humanized light chain locus is used for the generation of transgenic animals . Example 9,.
Silencing of the mouse λ I chain locus.
In a related embodiment, the Ig light chain locus further comprises a human Igk constant region.
Thus, the vector comprises a heterologous heavy chain locus.
In some such methods, the human kappa light chain locus is the inserted KCo5 transgene.
In one aspect, the mouse comprises a functional λ light chain locus.
In a specific aspect, the endogenous λ light chain locus is deleted in part or completely.
In one embodiment, the mouse comprises a nonfunctional k light chain locus.
In another preferred embodiment, the artificial heavy chain locus contains artificial constant region genes.
Figure 5 is a schematic depiction of the rabbit immunoglobulin light chain locus.
Example 8 Construction of a humanized rabbit light chain locus containing multipe human Vk elements.
In some apsects, the mouse comprises a functional λ light chain locus.
In one aspect, the modified immunoglobulin heavy chain locus lacks an endogenous ADAM6 gene.
In one aspect, the mouse comprises a nonfunctional λ light chain locus.
In one embodiment, the human Igλ light chain locus comprises the entire human Igλ locus.
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