Examples of 'chemokine receptor' in a sentence
Meaning of "chemokine receptor"
Chemokine receptor: A type of receptor found on the surface of certain cells that interacts with chemokines, which are proteins that play a key role in immune responses by inducing directed chemotaxis in nearby responsive cells
How to use "chemokine receptor" in a sentence
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chemokine receptor
Cyclic derivatives as modulators of chemokine receptor activity.
The typical chemokine receptor is a seven transmembrane receptor.
New piperidinyl derivatives as modulators of chemokine receptor activity.
Chemokine receptor antagonists and methods of use thereof.
Modulation may refer to antagonism of chemokine receptor activity.
Chimeric chemokine receptor polypeptides.
Also disclosed is a method for producing a chimeric chemokine receptor.
A candidate antagonist of a chemokine receptor is first identified in a conventional assay.
These compounds may be useful as modulators of chemokine receptor activity.
Duffy chemokine receptor.
In one embodiment the cell surface receptor is a chemokine receptor.
Isolating the chimeric chemokine receptor from the cell or medium.
The compounds described herein were previously identified as chemokine receptor modulators.
Solid forms of a chemokine receptor antagonist and methods of use thereof.
Any molecule or compound can be screened for chemokine receptor antagonist activity.
See also
The antagonist of chemokine receptor function can comprise a variety of bicyclic moieties.
Processes for preparing cyclic derivatives which are modulators of chemokine receptor activity.
The chimeric chemokine receptor would also be useful in modulator design efforts.
Standard flow cytometry procedures were employed in the chemokine receptor binding assay.
The two chemokine receptor targeting agents may be the same or different.
Peptide linkers are advantageous when the chemokine receptor targeting agent is proteinaceous.
Also described herein is a method of identifying a compound that binds to a chemokine receptor.
A hallmark of chemokine binding to a specific chemokine receptor is a change in intracellular calcium levels.
The present invention relates in general terms to an isolated chimeric chemokine receptor.
The conjugates that contain a chemokine receptor targeting agent are also provided.
These binding assays can also identify modulators of chemokine receptor binding.
The chemokine receptor targeting agent targets cells that express chemokine receptors.
The present application seeks to provide alternative chemokine receptor binding compounds.
Modulation of a chemokine receptor function includes both inducement and inhibition of the function.
The protein encoded by this gene is a member of the beta chemokine receptor family.
Chemokine receptor ligands have been reviewed by Gao and Metz Chem.
Describes pyrrolidine and piperidine compounds which are useful as modulators of chemokine receptor activity.
Also provided are conjugates that contain a chemokine receptor targeting agent and a targeted agent.
The genes encode novel proteins exhibiting structure and motifs characteristic of a chemokine receptor.
In addition PBMCs were harvested and analyzed for chemokine receptor expression on different cell subsets.
A membrane preparation is then made from the transfected cells expressing the chemokine receptor.
Direct detection of ligand binding to a chemokine receptor may be achieved using the following assay.
Such compounds may also be used in the screening of drugs for chemokine receptor binding.
Receptors belonging to the chemokine receptor family ( CCRs and CXCRs ) were analyzed.
This method may advantageously be used to engineer cell lines that express a chimeric chemokine receptor.
This gene is mapped to the region where the chemokine receptor gene cluster is located.
Detailed Description of the Invention The present invention relates to an isolated chimeric chemokine receptor.
An isolated chimeric chemokine receptor comprising,.
The phospholipase C assay can also be exploited to identify modulators of chemokine receptor activity.
A fusión inhibitor, or a chemokine receptor blocker may also form a part of the treatment.
The most recently described receptor of this nature is a chemokine receptor Graham et al.
In addition to the mammalian chemokine receptors, two viral chemokine receptor homologs have been identified.
In one embodiment, the receptor is a chemokine receptor.
The chemokine receptor antagonist and the cyclosporin can be administered simultaneously, separately or sequentially.
In an embodiment, the cell expresses a chemokine receptor.
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Examples of using Receptor
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Receptor is not sensitive to the type of change
Is that why that receptor network existed
This receptor can exist in three conformations
Examples of using Chemokine
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This chemokine is constitutively expressed in the lung
Cyclic derivatives as modulators of chemokine receptor activity
Chemokine antagonists or inhibitors of cytokine synthesis
