Examples of 'chlorotoxin' in a sentence
Meaning of "chlorotoxin"
chlorotoxin: (noun) a small peptide derived from scorpion venom that has shown potential for cancer treatment due to its ability to bind to certain cancer cells
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- A 36-amino acid peptide found in the venom of the deathstalker scorpion (Leiurus quinquestriatus). It blocks small-conductance chloride channels.
How to use "chlorotoxin" in a sentence
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chlorotoxin
Chlorotoxin polypeptides and conjugates and uses thereof.
Compositions that include the chlorotoxin conjugate are provided.
Radiolabeled chlorotoxin can be detected by positron emission tomography scanning.
Duration of paralysis depends on the amount of chlorotoxin injected.
Chlorotoxin binds preferentially to glioma cells compared to normal brain.
Compositions that include the chlorotoxin conjugate are described herein.
The composition includes a pharmacologically effective amount of a chlorotoxin conjugate.
Chlorotoxin has a considerable sequence homology to the class of small insectotoxins.
Six out of seven neuroblastomas were positive for chlorotoxin binding.
Chlorotoxin is a type of neurotoxin.
Methods for making the chlorotoxin conjugates are also described herein.
This is consistent with earlier evidence of specificity of chlorotoxin binding to gliomas.
The chlorotoxin is a targeting agent that directs the conjugate to a tissue of interest.
Compositions comprising a modified chlorotoxin peptide of the invention are also provided.
The invention provides for treating a tissue using the chlorotoxin conjugates.
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The chlorotoxin conjugates of the invention target and are bound by chlorotoxin binding sites.
The neuroectodermal tumor specific ligand is chlorotoxin fused to a cytotoxic moiety.
Concentration of chlorotoxin employed in this assay ranged from micoromolar down to nanomolar concentrations.
The invention provides for detecting a tissue using the chlorotoxin conjugates.
The fluorescent chlorotoxin conjugate of the invention may include other useful agents.
The growth of a tumor may be retarded by administering chlorotoxin to tumor simultaneously with temozolomide.
Corresponding polypeptide toxins of other scorpion species display similar or related activity to chlorotoxin.
The chlorotoxin or chlorotoxin derivative polypeptide is then isolated from the host cells and purified.
Suitable fluorescent compounds include a functional group that renders the compound chemically reactive toward the chlorotoxin.
Chlorotoxin is a small toxin and at pH 7 is highly positively charged.
Figure 2 depicts the effect of chlorotoxin on temodar efficacy in vivo.
The chlorotoxin may be native, synthetic or recombinant chlorotoxin.
Figure 4 illustrates that biotinylated chlorotoxin immunohistochemically stains pheochromocytomas.
The chlorotoxin may be native chlorotoxin, synthetic chlorotoxin, or recombinant chlorotoxin.
Figure 3 depicts the effect of chlorotoxin pretreatment on hydroxyurea efficacy in vivo.
Figure 8 shows immunohistochemical staining of normal skin with biotinylated chlorotoxin.
Figure 3 shows chlorotoxin staining of an adrenal mass neuroblastoma tumor.
Figure 11 shows the immunohistochemical staining of a medulloblastoma tumor with biotinylated chlorotoxin.
The histopath report identified chlorotoxin and maurotoxin, consistent with a deathstalker scorpion.
Figure 2 demonstrates that normal brain is not immunohistochemically stained by biotinylated chlorotoxin.
Figure 10 shows that biotinylated chlorotoxin does not immunohistochemically stain normal lung tissue.
Where the present invention relates to treatment, a cytotoxic agent is linked to chlorotoxin.
In another embodiment, the fluorescent chlorotoxin conjugate has a prolonged half-life in vitro.
Chlorotoxin binds to a surface protein overexpressed by many types of tumors, including brain cancer.
Other researchers are currently conducting human trials using chlorotoxin to slow cancer 's spread.
Examples of chlorotoxin variant peptides include, but are not limited to the following sequences,.
Figure 9 shows immunohistochemical staining of small cell lung carcinomas with biotinylated chlorotoxin.
Where the invention relates a treatment, the chlorotoxin or a derivative thereof is linked to a cytotoxic agent.
Figure 5 illustrates that normal adrenal tissue is not immunohistochemically stained by biotinylated chlorotoxin.
Table 1 depicts the sequence of chlorotoxin and sequences of exemplary reduced lysine chlorotoxin polypeptides.
Figure 15 demonstrates that normal spleen tissue is not immunohistochemically stained by with biotinylated chlorotoxin.
In one aspect, the chlorotoxin conjugates allows for intra-operative visualization of cancerous tissues.
Figure 14 shows the lack of immunohistochemical staining of normal liver tissue with biotinylated chlorotoxin.
Figure 7 illustrates biotinylated chlorotoxin immunohistochemical staining of melanoma tumor cells metastasized to the lung.
Similarly, suitable fluorescent compounds retain their fluorescent properties after conjugation to the chlorotoxin.
