Examples of 'clusterin' in a sentence
Meaning of "clusterin"
clusterin (noun) - A protein found in the human body that is associated with various physiological processes, including cell death and immune response
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- A heterodimeric glycoprotein associated with apoptosis.
How to use "clusterin" in a sentence
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clusterin
The sequences of numerous clusterin species are known.
Secreted clusterin is internalized in cancer cells.
Both trastuzumab concentrations upregulated clusterin protein expression.
Human clusterin was immobilized on a sensor chip.
The effect of treatment with oligonucleotides on clusterin protein expression was evaluated.
Clusterin is expressed in human pancreatic tumors.
Our results are consistent with the hypothesis that clusterin is an antiinflammatory agent.
The human clusterin gene promoter region has been published.
The analyte of interest to be quantified by using the invention was the protein clusterin.
Clusterin is a widely distributed glycoprotein with a wide range of biologic properties.
The humanized antibody of the present invention has a high affinity for clusterin.
Clusterin may preserve cell interactions that are otherwise perturbed by renal insults.
Figure 9 shows a calibration curve of the chosen clusterin peptide.
The composition may comprise clusterin or an analog or derivative thereof having clusterin activity.
For example, the promoter for transferrin or clusterin may be used.
See also
Preferably, the clusterin should be combined with a suitable carrier.
Figure 7 shows the mass spectrum from the retention profile of the labelled peptide from clusterin.
For instance, level of expression of clusterin can be particularly well determined in plasma.
Clusterin or epitope-containing portions of clusterin may also be used in the generation of vaccines.
Antiapoptotic proteins, such as clusterin and survivin, are often expressed in cancer cells.
One clusterin peptide with the amino acid sequence depicted below was used as a reference,.
Accordingly, ADDL formation in the absence of clusterin further was characterized in this Example.
Clusterin silencing in human lung adenocarcinoma cells induces a mesenchymal-to-epithelial transition through modulating the ERK / Slug pathway.
Among patients with AD, higher clusterin levels were associated with more severe disease.
Figure 8 shows an accumulated MS / MS spectrum of the labelled peptide from clusterin.
On the other hand, clusterin mRNA levels did not increase after dexamethasone treatment.
Characteristically FDCS have mircotubuloreticular structures ( MTRS ) and increased levels of intracellular clusterin.
EXAMPLE 3 Effect of combined treatment with clusterin ASO and trastuzumab on the induction of apoptosis.
The clusterin gene has been studied in mouse, rat, and human.
H16B5 inhibits the internalization of secreted clusterin in cancer cells.
Example 6 . anti-clusterin antibodies may bind to clusterin variants.
Figure 8 shows the MS / MS spectrum of the labelled peptide from clusterin.
In humans, clusterin is encoded by the CLU gene on chromosome 8.
Furthermore, cyclosporine A ( CsA ) increases clusterin mRNA levels in the rat kidney.
Complement 6, clusterin in individuals with AMD, as compared to controls.
The isoelectric point ( pI ) of the predominant electrophoretic form of clusterin from ram RTF is 3.7.
The clusterin surface was regenerated between each antibody injection with 50 µl 1 of 20mM HCl.
EXAMPLE 2 Effect of combined treatment with clusterin ASO and trastuzumab on BT474 cell growth rate.
Clusterin or " TRPM-2 " is a ubiquitous protein, with a diverse range of proposed activities.
They include clusterin precursor, inter alpha-trypsin inhibitor, apolipoprotein A2 and alpha2 HS glycoprotein.
Clusterin protein expression and poly ( ADP-ribose ) polymerase ( PARP ) cleavage were analyzed by Western blot.
