Examples of 'co-stimulatory' in a sentence
Meaning of "co-stimulatory"
Co-stimulatory describes a type of biological signal or molecule that is involved in the process of stimulating immune responses, often related to the activation of T-cells
How to use "co-stimulatory" in a sentence
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co-stimulatory
These proteins are also known as co-stimulatory molecules.
A second co-stimulatory signal is required.
The modulatory domain can be a co-stimulatory domain.
Additional co-stimulatory domains will be apparent to those of skill in the art.
Several molecules have been shown to enhance co-stimulatory activity.
The expression of co-stimulatory molecules is a defining feature of professional antigen-presenting cells.
To which are fused the signaling and co-stimulatory domains.
Co-stimulatory receptors provide the second signal which can be either activating or inhibitory.
A very attractive approach is to target co-stimulatory cell pathways.
The beneficial co-stimulatory environment can be augmented or ensured through the use of immunopotentiating agents.
The cell may or may not express co-stimulatory molecules.
The tumor antigen and co-stimulatory molecules may be encoded by the same recombinant poxvirus vector.
The mutation in the LIGHTm molecule affects its co-stimulatory effect.
This coincides with low expression of co-stimulatory molecules and limited ability to secrete certain cytokines.
In a second preferred embodiment, the immunomodulatory antibody stimulates a co-stimulatory receptor.
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Presumably, this is controlled both by the co-stimulatory complexes as well as cytokine milieu.
Nevertheless, this challenge can be addressed by protocols including agents inducing co-stimulatory blockade.
More particularly, the composition is an inducible co-stimulatory polypeptide and is induced by ligand oligomerization.
It was also examined if tumor cell antigen presentation depended on co-stimulatory molecules.
Typically, the cytoplasmic domains from these co-stimulatory polypeptides are used in the expression vector.
Provided herein, said second polypeptide may comprises one or more co-stimulatory domains.
This molecule can receive a co-stimulatory signal delivered by a ligand on B-cells or other APCs.
In an instance, the antigen binding member does not comprise a co-stimulatory signaling domain.
Co-stimulatory signals are essential for the activation of naïve T cells and productive immune response.
This alteration gives enhanced delivery of co-stimulatory signals and cytokine help.
Co-stimulatory domains from other proteins may also be used with the CAR of the invention.
The use of combinations of SCMs containing different co-stimulatory domains is also envisaged.
Co-stimulatory molecules are those accessory molecules that promote the growth and activation of the T cell.
Figure 9 is several graphs depicting induction of co-stimulatory molecule expression on dendritic cells by CpG.
An immunoresponsive cell comprising a receptor that binds an antigen and an exogenous co-stimulatory ligand.
The frequencies of monocytes subsets, and expression of co-stimulatory molecules were performed by flow cytometry.
This phenomenon may explain the sometimes conflicting data reported by workers studying these co-stimulatory molecules.
The ability to activate T-cells by cytokines or co-stimulatory molecules is thus extremely important.
In some embodiments, the interfering RNA specifically targets mRNA encoding a negative co-stimulatory molecule.
The co-stimulatory polypeptide provides a co-stimulatory signal that enhances the T lymphocyte 's response to the particular antigen.
Accordingly, it is considered that the matrix molecule will function as a co-stimulatory factor of lymphocytes.
Maturation and co-stimulatory surface markers were highly induced by TIR ligands and SEB.
The foregoing is preferably accomplished by co-injection of the antigen and the co-stimulatory composition.
The composition can further include co-stimulatory molecules to stimulate T cells.
This embodiment is particularly useful for testing the capacity of compounds as co-stimulatory molecules.
These targets also often lack important co-stimulatory ligands for maximal T cell activation.
For example, the endodomain can contain an intracellular signaling domain and optionally a co-stimulatory signaling region.
The clonal expansion of T cells following TCR and co-stimulatory receptor engagement requires tremendous synthetic demands.
FabB is derived from an antibody which bids a cell surface co-stimulatory molecule.
Co-stimulatory signaling systems-which are required to fully launch immune.
The additional use of genes encoding cytokines or co-stimulatory molecules may pose additional risks.
The application includes a kit for specifically inducing proliferation of a T cell expressing a known co-stimulatory molecule.
The T cells are maintained in contact with the co-stimulatory ligand throughout the culture term.
Any co-stimulatory motif, or functional portion thereof, may be used.
Examples of immune modulators useful in the present invention include cytokines, co-stimulatory molecules, and chemokines.
