Examples of 'coactivator' in a sentence
Meaning of "coactivator"
A coactivator is a noun used in molecular biology to describe a molecule or compound that enhances the activity of an enzyme or protein
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- Any protein that binds to an activator as part of gene transcription
How to use "coactivator" in a sentence
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coactivator
This protein was used in the coactivator peptide recruitment assay.
This protein contains a bromodomain and is thought to be a nuclear receptor coactivator.
The coactivator is unable to bind DNA by itself.
This may be due to a coactivator.
The coactivator domain and the DNA binding domain are tethered together to form a tethered coactivator.
Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes.
Novel transcription coactivator complex containing activating signal cointegrator 1.
Agonist ligands function by inducing a conformation of the receptor which favors coactivator binding.
This reporter allows ER and the tethered coactivator to bind simultaneously at the promoter.
Alphascreen assay Activity on FXR was assayed by using Alphascreen technology in a recrutiment coactivator assay.
Use of a tethered coactivator comprising,.
Activated Wts can then go on to phosphorylate and inactivate the transcriptional coactivator Yorkie Yki.
Furthermore, the ratio of coactivator to corepressor protein varies in different tissues.
Activity on FXR was assayed by using Alphascreen technology in a coactivator recruitment assay.
Recruit coactivator or corepressor proteins to the transcription factor-DNA complex.
See also
SRC steroid receptor coactivator.
The two types of coactivator are essential for ER-mediated transcriptional activation.
It is a ligand-dependent nuclear receptor transcription coactivator.
The interfaz is involved with binding of coactivator or co-repressor polypeptides.
It is a coactivator for steroid hormones, and the synthesized protein is involved in clathrin-mediated endocytosis.
Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1Ī± to enhance fatty acid metabolism.
Nuclear receptor coactivator 2 has been shown to interact with:.
MED1 functions as a nuclear receptor coactivator.
Pin1 can also affect coactivator interactions with transcription factors.
The activity increase is 4 times when HIBAO is used as a coactivator.
Conclusion, metallocene and coactivator can be fed together or separately into the reactor.
EMSA studies showed that 2-methylcitrate probably functions as a coactivator of PrpR.
This argues that Trabid acts to control coactivator recruitment to the TCF-B-catenin complex.
Second, in a hitherto unrecognized step, the ER triggers the activity of coactivator complex.
This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers.
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC - 1.
MAML3 encodes a transcriptional coactivator involved in Notch signaling.
The AP-1 proteins Jun and Fos also increase the activity of their coactivator CBP.
Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription ( 9 ).
The PPARĪ“ / coactivator.
A method according to any one of claims 1-6 in which the nuclear protein is a coactivator.
Nuclear receptor coactivator 3.
In examples 9 and 13 coactivator is TIBAO and activity is 2 times higher with methylene substituted compound.
This points to a central role for ER/p160 contacts in potentiation of coactivator function.
TR-FRET Coactivator Assay Lanthascreen assay ( Invitrogen ) was used for nulear receptor selectivity assay.
Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP).
Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to interact with:.
RIP140 is able to act as a corepressor or as a coactivator and can interact with LXRs.
SRm160 is another coactivator that has been proposed to enhance mRNA 3' end processing.
Figures 6A-6B present a model for ER interaction with the coactivator complex.
General transcriptional coactivator PC4 activates p53 function.
Exemplary AR and ER coregulatory proteins which are SPOP substrates include the p160 coactivator family proteins.
CAR, Coactivator Recruitment ( Lanthascreen ) Table 8 shows the results of these assays.
Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.
CAR: Coactivator Recruitment (Lanthascreen)Table 6 shows the results of these assays.
