Examples of 'cobimetinib' in a sentence
Meaning of "cobimetinib"
cobimetinib (adjective) - Related to a medication used in the treatment of certain types of cancer, often in combination with other drugs
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- A mitogen-activated protein kinase inhibitor used, in combination with vemurafenib to treat melanoma
How to use "cobimetinib" in a sentence
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cobimetinib
Cotellic contains the active substance cobimetinib.
Cobimetinib is the predominant moiety in plasma.
Standard genotoxicity studies with cobimetinib were negative.
Effects of cobimetinib on other medicinal products.
There are no data in humans for cobimetinib.
Effects of cobimetinib on drug transport systems.
Carcinogenicity studies have not been conducted with cobimetinib.
It is not known whether cobimetinib is excreted in human breast milk.
There is no specific antidote for overdosage with cobimetinib.
Cobimetinib and its metabolites were characterised in a mass balance study in healthy subjects.
The active substance is cobimetinib.
Cardiovascular safety of cobimetinib in combination with vemurafenib has not been evaluated in vivo.
No dedicated fertility studies in animals have been performed with cobimetinib.
In case of suspected overdose, cobimetinib should be withheld and supportive care instituted.
No studies have been conducted to investigate the pharmacokinetics of cobimetinib in paediatric patients.
See also
Cobimetinib is a substrate of P-gp in vitro.
Cotellic is an anti-cancer medicine that contains the active substance cobimetinib.
Caution should be exercised if cobimetinib is coadministered with moderate CYP3A inhibitors.
Cobimetinib is not indicated for treatment of patients with wild-type BRAF melanoma.
What Cotellic is Cotellic is an anti-cancer medicine that contains the active substance cobimetinib.
Conclusions, Vemurafenib and cobimetinib can be combined safely at their respective single-agent MTDs.
What Cotellic contains · The active substance is cobimetinib.
Each film-coated tablet contains cobimetinib hemifumarate equivalent to 20 mg cobimetinib.
When cobimetinib is co-administered with a moderate CYP3A inhibitor, patients should be carefully monitored for safety.
Package leaflet, Information for the patient Cotellic 20 mg film-coated tablets cobimetinib.
Mild CYP3A inhibitors, Cobimetinib can be co-administered with mild inhibitors of CYP3A without dose adjustment.
Cobimetinib is a substrate of P-glycoprotein P-gp.
In vitro data indicate cobimetinib is not an inhibitor of OAT1, OAT3 or OCT2.
In vitro, cobimetinib is a moderate inhibitor of BCRP ( Breast Cancer Resistance Protein ).
