Examples of 'compstatin' in a sentence
Meaning of "compstatin"
Compstatin is an adjective related to compstat, a data-driven management process used in policing
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- A cyclic tridecapeptide that is used to treat problems with the human complement system
How to use "compstatin" in a sentence
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compstatin
Compstatin analogs with improved pharmacokinetic properties.
Activity of expressed compstatin and its analogs.
The compstatin analog moieties can be identical or different.
The compound may be a compstatin analog.
Compstatin analogs with improved activity.
Activity of the PEGylated compstatin analog.
The binding of compstatin peptides was also investigated using isothermal titration calorimetry.
In certain embodiments the second agent is a compstatin analog.
The compstatin analog is incubated with the fragment and crosslinking is initiated.
Structural information may be used to design compstatin mimetics.
Compstatin and its analogs have significant potential for clinical applications.
Depot formulations containing a compstatin analog may be used.
Compstatin analogues for use in the treatment of inflammatory conditions of the respiratory system.
Activity of additional synthetic compstatin analogs.
Concatamers or multimers of a compstatin analog thereof are also of use in the present invention.
See also
The polymeric backbone or scaffold is reacted with the compstatin analogs.
A number of fragments and variants of compstatin inhibit complement have been identified.
Compstatin analogs that have higher complement inhibiting activity than compstatin have been developed.
The invention encompasses administration of a compstatin analog in combination with additional therapy.
A combination of gene expression and synthetic methods may also be utilized to produce compstatin analogs.
A variety of compstatin analogs that have higher complement inhibiting activity than compstatin have been synthesized.
Typically the isolated graft has many molecules of compstatin analog attached thereto.
Extraction of compstatin analogs from plasma samples by SPE.
The carboxy-terminal residue of compstatin is threonine.
In some embodiments a compstatin analog moiety is attached at each end of a linear PEG.
Activity of the albumin binding protein-conjugated compstatin analog.
Such compstatin analogs are referred to herein as “ targeted compstatin analogs ”.
A supramolecular complex comprising a compstatin analog is of use in the Invention.
For example, a compstatin analog may be incorporated into or encapsulated in a microparticle or nanoparticle formulation.
In some embodiments, the present invention provides a compstatin analog conjugated to a polymer.
The cell-reactive compstatin analog thus becomes covalently attached to the cell.
In some embodiments the method comprises administering a cell-reactive compstatin analog to the subject.
In general, a cell-reactive compstatin analog can be synthesized using a variety of approaches.
In some aspects, the invention provides a pharmaceutical grade composition comprising a cell-reactive compstatin analog.
In other embodiments, a targeted compstatin analog does not comprise a cell-reactive moiety.
In some aspects, a CRM confers depot properties on a compstatin analog.
Table 1 provides a non-limiting list of compstatin analogs useful in the present invention.
Certain compstatin analogs having improved activity incorporate one or more non-standard amino acids.
In some aspects, the invention provides an isolated cell having a compstatin analog covalently attached thereto.
In certain embodiments, the compstatin analog is a compound that comprises a peptide having a sequence,.
In one embodiment, PEG is coupled to a lysine residue added to the C-terminus of compstatin.
In some embodiments, a targeted compstatin analog comprises both a targeting moiety and a cell-reactive moiety.
Such binding is a characteristic of the interaction of compstatin with C3.
The structure of compstatin revealed a molecular surface that comprises of a polar patch and a non-polar patch.
In some embodiments, a linkage between a CRM and a compstatin analog comprises an amide.
In some embodiments, a compstatin analog is directly linked to a CRM vía a carbamate.
Thermodynamic characterization of the interaction of additional compstatin analogs with C3.
In some embodiments, a compstatin analog is directly linked to a CRM vía an amide.
In some embodiments, the analogs have at least 50-fold greater activity than does compstatin.
Docking of compstatin analogs into the binding site of C3c.
