Examples of 'constant regions' in a sentence
Meaning of "constant regions"
constant regions: In biological terms, constant regions are specific parts of antibodies or other proteins that remain consistent and unchanged, in contrast to variable regions which can differ
How to use "constant regions" in a sentence
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constant regions
Human constant regions are known in the art.
Antibodies are comprised of variable and constant regions.
Gamma constant regions assist in affinity maturation of antibodies.
Of particular interest would be IgG constant regions.
Light chain constant regions can be lambda or kappa.
Single underlining indicates constant regions.
Constant regions of the ligands are shown in lower case.
The antibody may have human constant regions.
The constant regions of a humanized antibody if present generally are human.
Human and murine constant regions.
Light chain constant regions are shown with a checkerboard pattern.
It is composed of murine variable regions and human constant regions.
The constant regions are typically responsible for effector function.
A preferred peptide tag comprises the constant regions of an immunoglobulin.
Some such constant regions have no additional mutations present.
See also
Nonlimiting exemplary light chain constant regions include λ and k.
The constant regions of humanized antibodies are derived from human immunoglobulins.
Cloning immunoglobulin constant regions.
One or more of the constant regions can be human or effectively human.
Such variable regions can be combined with human constant regions.
Infliximab has human constant regions and murine variable regions.
The main immunogenicity is mediated by the heavy chain constant regions.
Reverse primers are located in the constant regions of heavy and light chains.
A chimeric antibody may also contain truncated variable or constant regions.
Nonlimiting exemplary heavy chain constant regions also include e and µ.
The constant regions are in upper case and underlined in the protein sequences.
These can be combined with genomic constant regions of human origin.
The constant regions of the subject antibodies are derived from human immunoglobulins.
The vector also has human leader and constant regions.
Constant regions are also thought to influence the stabilities of the different immunoglobulins.
It is understood that either kappa or lambda constant regions can be utilized.
Amplified constant regions were subcloned into pENTRIA dNotI in which NotI was deleted.
The humanized immunoglobulins may or may not contain constant regions.
One of skill will appreciate that constant regions in primer sequences are optional.
The constant regions of the chimeric antibodies are derived from human immunoglobulins.
All these before mentioned allotypes are expressed on constant regions of the immunoglobulin.
For instance constant regions of immunoglobulins can be obtained by papain digestion of antibodies.
The light and heavy chains comprise variable and constant regions.
The constant regions of the antibody of the present invention are not particularly limited.
A light chain is joined to a heavy chain by disulfide bonding through constant regions.
Additional amino acids in the framework or constant regions of such antibodies may be altered.
Each heavy chain is comprised of a variable region and three constant regions.
The remaining constant regions of the heavy chains are aligned with each other.
Light chain can be divided into k or λ chain considering of different constant regions.
In the chimeric approach the constant regions are replaced with corresponding human sequences.
Other allotypic and isoallotypic variants of the illustrated constant regions are included.
Human antibody constant regions are used as the constant regions of the chimeric antibodies.
Antibody molecules may further comprise antibody constant regions or parts thereof.
The constant regions also can be altered to obtain desirable or more desirable effector properties.
It should be appreciated that any species of variable and constant regions may be used.
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