Examples of 'constitutively active' in a sentence
Meaning of "constitutively active"
constitutively active: This phrase is used in biology and biochemistry to describe proteins or enzymes that are constantly active or functioning, regardless of external signals or conditions. It implies a steady state of activity without the need for additional stimuli
How to use "constitutively active" in a sentence
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constitutively active
Inducible or constitutively active sequences can be used.
In other embodiments the cGAS is constitutively active.
Inducible or constitutively active sequences may be used.
This form of TAZ always resides in the nucleus and therefore is constitutively active.
Both kinases are constitutively active and indistinguishable in transfection studies.
Partial digestion of protein kinase C with trypsin yielded a constitutively active fragment.
Such promoters may be constitutively active or they may be active only temporarily.
In a preferred embodiment, the receptor is constitutively active.
Control elements may be constitutively active or may be inducible under defined circumstances.
In addition, the cGAS may be constitutively active.
Clones expressing the constitutively active Calcineurin transcript were selected for further analysis.
In one embodiment, the promoter is constitutively active.
The housekeeping proteasome is constitutively active in all peripheral cells and tissues of the body.
Thus, the internal promoter may be constitutively active.
EGFRvIII is constitutively active thus it does not require the ligand EGF for activation.
See also
Useful mutations include those that result in constitutively active forms of the encoded protein.
As examples of constitutively active mutants, constitutively active forms of CaN have been described.
These mutations in bRaf result in a constitutively active MAP kinase cascade.
The constitutively active TrkB signals through multiple pathways to promote cancer initiation, progression and metastasis.
The invention also is useful with constitutively active expression control sequences.
In addition, agonistic forms of the protein may be generated which are constitutively active.
The condition may be a constitutively active NF-kB cancer.
The invention also discloses the conversion of wild type p53 to a constitutively active form.
It is a constitutively active ion-channel.
Alternatively, a promoter may be a constitutively active promoter.
As a further example, constitutively active CaMKIIa silences all hypertrophy-sensitive genes in cardiomyocyte cultures.
Furthermore, the cGAS may be constitutively active.
A cDNA encoding a constitutively active form of the calcineurin A catalytic subunit O'Keefe et al.
In these cells, the mTOR pathway is constitutively active.
Oncogenic mutations, leading to constitutively active kinases, can transform normal cells to cancer cells.
This allows for constitutive, yet periodic and infrequent expression of the constitutively active polypeptide.
The expression promoter may be constitutively active or inducible, as is known in the art.
In addition, agonistic forms of PYY may be generated which are constitutively active.
However, we will have to use a constitutively active form of the enzyme for our tests.
In this assay, no Hh protein was added because the reporter-construct is constitutively active already.
These variants constitute potentially constitutively active proteins having a non-modulable and possibly enhanced activity.
Constitutively active MKK6 was generated according to Raingeaud et al.
Expression of the bait-fusion protein is driven by a constitutively active actin promoter.
The promoter Ptac is constitutively active in Salmonella spp ., as these organisms lack laql.
In isolation, the VCA region is constitutively active.
Also, constitutively active EGFR has been found in gliomas, breast cancer and lung cancer.
TSC2 null cells have constitutively active mTOR.
Constitutively active MXK6 was generated in a manner similar to Raingeaud et al . Mol.
Both GSK3 isoforms are constitutively active in resting cells.
Constitutively active MKK6 was generated in a manner similar to Raingeaud et al . Mol.
PDK1 is expressed ubiquitously and is a constitutively active kinase.
The B2 receptor is constitutively active and participates in bradykinin 's vasodilatory role.
Mice deficient of uPAR are protected from proteinuria unless a constitutively active B3 integrin is expressed.
This pathway is constitutively active at a low level through spontaneous cleavage of C3.
The promoter may be inducible, repressible, or constitutively active.
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Integral person member active in his environment
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