Examples of 'convertase' in a sentence
Meaning of "convertase"
convertase (noun) - A type of enzyme that catalyzes the conversion of one substance into another, often found in biochemical processes in the body
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- Any of several enzymes that convert a compound into smaller, biologically-active compounds
How to use "convertase" in a sentence
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convertase
The protein may function as a proprotein convertase.
Identification of prohormone convertase substrate specificity.
The convertase inhibitor is an inhibitor of furin.
The prototypical proprotein convertase is furin.
Convertase inhibitors may be used in a range of internal wound healing applications.
The conversion of prohepcidin to hepcidin is mediated by the prohormone convertase furin.
Such prophylactic use is a preferred use of convertase inhibitors according to the invention.
In one embodiment the host cell constitutively expresses a prohormone convertase.
Convertase inhibitors used according to the invention may be proteins or have peptidyl components.
These sequences may comprise the cleavage site of prohormone convertase or of carboxypeptidase E.
The convertase inhibitors may also be used for the treatment or prevention of fibrosis.
In preferred embodiments, isolated prohormone convertase is utilized.
The convertase inhibitor may be a serine protease inhibitor and is preferably a thiol inhibitor.
Such inhibitors are able to reduce convertase activity prior to de-granulation.
This convertase is highly expressed in liver, intestine and kidneys.
See also
Cleavage in the extracellular region may involve a furin-like convertase.
Murine prohormone convertase 2 does not cleave the wildtype prorelaxin.
Furin is an enzyme which belongs to the subtilisin-like proprotein convertase family.
Of particular interest is prohormone convertase nucleic acid that encodes a full-length polypeptide.
In another embodiment, the host cell is stably transformed with a prohormone convertase.
Furin is a subtilisin-like convertase involved in postranslation endoproteolytic processing of various pro-hormones.
In some preferred embodiments, the nucleic acid sequence includes the prohormone convertase signal sequence.
The half-lives of the convertase inhibitors may be short for a number of reasons which include,.
O Claire Dubois ' examination of the roles of the proprotein convertase furin in platelet functions.
TNF-a convertase is a metalloproteinase involved in the formation of active TNF-a.
There remains a need for effective MMP and TNF-a convertase inhibiting agents.
C5 convertase leads to the assembly of the MAC vía the lytic pathway.
This assay measures the ability of deposited C3b to form a functional C3bBbP convertase.
Conversion to iC3b prevents convertase formation and subsequent lysis in serum / EDTA.
The relaxin ( Rx ) mutants have the following sequence in the prohormone convertase cleavage site.
A preferred water-soluble convertase inhibitor suitable for use according to the invention is L-hexaarginine.
C3bBbP is the alternative pathway convertase.
This gene encodes a proprotein convertase from the proteinase K subfamily, of the secretory subtilase family.
Mutations that increase the stabilisation of the C3 convertase by properdin.
The C3 convertase of the alternative pathway of human complement.
Can also be activated by means other than C5 convertase activity.
The generation of C5 convertase is the end of the lectin pathway.
The process includes the step of inhibiting properdin-induced stabilization of C3 convertase.
The alternative pathway C3 convertase is stabilized by the binding of properdin.
These together are called the C5 convertase.
Amplification of C3 convertase activity occurs as additional C3b is produced and deposited.
Properdin extends the alternative pathway C3 convertase half-life six to ten fold.
The C5 convertase in these complexes may be a C5 convertase of either the classical or alternative pathway.
Factor I deficient patients have large amounts of C3 convertase in the blood.
Inhibition of TNF-a convertase inhibits production of TNF-a.
A preferred inhibitor is an inhibitor that blocks C3 convertase and MAC assembly.
C3 convertase and amplification.
Kex.2 has been considered to be a prototypic proprotein convertase.
In pancreatic α-cells, prohormone convertase 2 action leads to the release of glucagon.
According to some embodiments of the invention, the sema3E is a pro-protein convertase resistant Sema3E.
