Examples of 'cremophor' in a sentence
Meaning of "cremophor"
Cremophor is a specific type of solubilizer or emulsifier used in pharmaceuticals and other industries to improve the solubility of poorly soluble drugs
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- A polyethoxylated derivative of castor oil
How to use "cremophor" in a sentence
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cremophor
Cremophor is slightly toxic in the tested concentration.
The preferred commercial product for example is Cremophor.
The cremophor currently used is polyethoxylated castor oil.
The vehicles used were either as aqueous buffers or a solutions containing Cremophor.
Cremophor is a polyoxyethylated castor oil.
Paclitaxel was initially dissolved in absolute ethanol with an equal volume of Cremophor.
Cremophor has been observed to cause serious or fatal hypersensitivity episodes.
Especially suitable are the various tensides available under the tradename Cremophor.
Cremophor in TAX inhibits transcytosis of paclitaxel across endothelial cells.
Especially suitable are the various tensides available under the trade name Cremophor.
Cremophor EL can cause severe anaphylaxis.
A range of such products is marketed by BASF under the trade description of Cremophor grades.
Cremophor EL is ethoxylated castor oil supplied from Sigma.
Particularly preferred is ethoxylated castor oil available for sale with the trade name Cremophor EL.
Cremophor EL is a condensation product of castor oil and ethylene oxide sold by BASF.
See also
Preferably the surfactant is a polyethoxylated hydrogenated castor oil Cremophor RH.
Miglyol has a low HLB and Cremophor has a high HLB.
The early human product was solubilized in a surfactant known as Cremophor EL.
Cremophor EL ® was weighed out into the main mixing vessel.
The polyoxyethylated castor oil is sold under the tradename Cremophor EL.
A variety of drugs are administered using Cremophor EL including cyclosporin, tacrolymus and teniposide.
Mouse tests prove that bile acid salts are less toxic than Cremophor EL.
Furthermore, by decreasing the relative amount of Cremophor EL, a less toxic vehicle is created.
Instead, it must be given to patients in a different solubilizing substance, called cremophor.
Preferably, the second component is Cremophor EL and the third component is propylene glycol.
Polyoxyethylated castor oil is commercially available under the tradename Cremophor EL from BASF Corp.
Cremophor RH40 is a preferred hydrophilic surfactant and a preferred lipophilic surfactant is oleic acid.
The biological and chemical equivalents or derivatives of Cremophor EL may also be used.
Similarly diluted and filtered Cremophor EL ® / ethanol solution was used as a control in the vehicle group.
Accordingly, currently used taxol formulations require a cremophor to solubilize the drug.
The longest surviving Cremophor control mouse lasted until 92 days post cancer cell injection.
The co-solvents with reference to i above are polyoxyethylene castor oil derivatives, particularly cremophor.
The determination of Pd-BPheid concentration in the Cremophor solution was performed by dilution into methanol.
In some embodiments, the surfactant is Cremophor.
Optionally Cremophor EL, ethyl alcohol or acid are added.
In another embodiment, the nanoparticle composition is free of Cremophor.
As a comparison, a commercially available paclitaxel in Cremophor composition is used at the same dose level.
Control animals received the same volume of solvent ( a mixture of ethanol and cremophor EL ).
Cremophor EL is a synthetic, nonionic surfactant.
A number of pharmaceutically acceptable surfactants are listed, with Cremophor EL ® being preferred.
The formulation does not include Cremophor EL ® which is considered to be allergenic.
However, Cremophor EL has been implicated in causing anaphylactic reactions in some patients.
Moreover, the formulation is very bitter due to the presence of Cremophor EL.
The solid dispersion of Example 3 containing Cremophor EL showed the second highest solubility.
Taxol-Cremophor is more toxic than Cremophor.
The surfactant is selected from polysorbate, vitamin E TPGS and cremophor, preferably cremophor.
Cremophor is diluted 1:1 with ethanol and stored sheltered from the light.
Rapamycin was dissolved in absolute ethanol and prepared in a final formulation of 8 % cremophor and 2 % ethanol.
Cremophor RH 40 was added to the bulk and mixed.
Suitable carriers include physiological saline, polyethylene glycol, ethanol, sesame oil, cremophor and isopropyl myristate.
