Examples of 'cyclophilin' in a sentence
Meaning of "cyclophilin"
Cyclophilin: a type of protein that plays a role in various cellular processes, including protein folding and immune response
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- Any of a class of proteins that bind to ciclosporin
How to use "cyclophilin" in a sentence
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cyclophilin
Never before cyclophilin has been described to be an allergen.
This gene encodes a member of the cyclophilin family.
Cyclophilin inhibition as potential therapy for liver diseases.
Never before a plant cyclophilin has been described to be an allergen.
Cyclophilin has also been implicated in certain types of cancer.
The most preferred protein is birch pollen cyclophilin.
Cyclophilin is believed to be responsible for mediating this immunosuppressive response.
These effects are related to a more pronounced cyclophilin binding affinity.
A complex comprising cyclophilin and a compound according to any preceding claim.
Of particular interest to the applicant are novel cyclophilin binding ligands.
Cyclophilin identified as an allergen.
More preferred the protein according to the invention is a cyclophilin.
Blots were probed for cyclophilin transcripts to attest to equal loading of mRNA.
The values are compared to the signals obtained with the cyclophilin.
Cyclosporins which bind strongly to cyclophilin but are not immunosuppressive have been identified.
See also
Cyclophilin is found in prokaryotic and eukarotic organisms and is ubiquitous and abundant.
This confirmed that several isoforms of the cyclophilin must exist.
But cyclophilin actually carries the ligand binding site on the outside of the barrel.
All blots were reprobed with a cyclophilin cDNA control to correct for loading error.
Results are promising with novels fragments identified that bind weakly to different cyclophilin proteins.
Hybridization with a cyclophilin probe indicates that mRNA for the tested samples are equally loaded.
Levels of RNA were normalized to the quantitated levels of cyclophilin mRNA.
Primer pairs specific for the Bactin and cyclophilin genes were used as control probes.
Cyclophilin A is a cytosolic and highly abundant protein.
We then demonstrated that cyclophilin A was associated with viral particles.
Cyclophilin B has also been implicated in cancer.
The data were normalized to the house keeping gene, cyclophilin.
We routinely used both Cyclophilin G and GUS to calculate a normalization factor for all samples.
In another embodiment, the cDNA is a TRIM5a cDNA or a cyclophilin fusión thereof.
Contacting a ligand with cyclophilin in the presence of a known substrate of cyclophilin ; and.
In other words, each isomer may exhibit a different binding affinity to cyclophilin.
Moreover, the development of species-specific cyclophilin inhibitors may also provide a route to novel anti-parasitic drugs.
All target gene values were normalized to a reference gene, constitutively expressed cyclophilin.
In this case, however, cyclophilin D levels were found to be the same in both groups.
As a control, rates were also determined for a parallel reaction that lacked cyclophilin.
SRB-1 mRNA levels were normalized to cyclophilin mRNA levels according to standard protocols.
If pharmaceutical is a cyclosporin, the binding competitor may be a cyclosporin analog that binds to cyclophilin.
APOC-III mRNA levels were normalized to cyclophilin mRNA levels according to standard protocols.
This suppression is accomplished by the binding of cyclosporine to the ubiquitous intracellular protein, cyclophilin.
Fig 2, Purification of birch pollen cyclophilin by phenylsepharose HP chromatography.
As a control, an initial rate constant was also determined for a parallel reaction that lacked cyclophilin.
Primers for cyclophilin A CypA were as published by Peinnequin et al . and Langnaese et al.
A value less than 1 means that the compound has an higher cyclophilin affinity than CsA.
Recombinant tomato cyclophilin is expressed in E. coli and identified by rotamase activity.
Ciclosporin prevents the dephosphorylation of NF-AT by binding to cyclophilin.
A PCR assay for cyclophilin E ( Ppie ) was used as template for the in vitro transcription.
Also of interest is the expression of BIP ( immunoglobulin heavy chain binding protein ) and cyclophilin.
Values were expressed relative to cyclophilin A. The sequences of the oligonucleotides used are described below.
In another embodiment, the third nucleic acid sequence encodes a fusión protein comprising TRIM 5a and cyclophilin.
Preferably said housekeeping gene is cyclophilin more preferably Cyclophilin A ( PPIA ).
