Examples of 'cytotoxic drug' in a sentence
Meaning of "cytotoxic drug"
cytotoxic drug - Pharmaceutical compounds designed to kill or inhibit the growth of cells, commonly used in chemotherapy to treat cancer and other diseases
How to use "cytotoxic drug" in a sentence
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cytotoxic drug
The chemotherapeutic drug is especially a cytotoxic drug.
Etoposide is a cytotoxic drug widely used in retinoblastoma chemotherapy.
The chemotherapeutic entity may be a cytotoxic drug.
A preferred cytotoxic drug is paclitaxel.
The preferred active substance to be delivered is a cytotoxic drug.
Any cytotoxic drug known in the art may be conjugated to a biMab.
Transduced cells are then selected based on their resistance to killing by a cytotoxic drug.
Discloses cytotoxic drug conjugates and their delivery to tumor cells.
Gemcitabine is a potent anti pancreatic cytotoxic drug used and positive control.
The cytotoxic drug may then be deposited on the surface of the microparticles.
There are a number of methods by which a cytotoxic drug may be associated with the microparticle.
The cytotoxic drug may become active once internalized in the cells.
A prodrug capable of being converted into a cytotoxic drug by the nitroreductase encoded by the vector.
The cytotoxic drug used for conjugation is thus selected on the basis of these criteria.
In trastuzumab emtansine there is also a cytotoxic drug which is delivered into the cancer cell.
See also
The problem lies with the eligibility criteria or exclusion criteria for the cytotoxic drug trials.
PRECAUTIONS General Fluorouracil is a cytotoxic drug with a narrow margin of safety.
Another aspect of the invention is a linker bound to an element M defined as a cytotoxic drug.
Preferably the compatible cytotoxic drug is fluorouracil, methotrexate or combinations thereof.
The ketone group can then specifically be conjugated with a cytotoxic drug in the second step.
In contrast, the cytotoxic drug cyclophosphamide depletes both circulating lymphocytes and neutrophils.
The enzymatic portion is capable of converting a prodrug into a cytotoxic drug that attacks tumor cells.
Once internalized, the cytotoxic drug will be released in certain active form and take effects.
This is compared with the MTD of the free cytotoxic drug.
In a preferred embodiment, the cytotoxic drug is gamma calicheamicin or N-acetyl calicheamicin.
In particular embodiments, the drug is a cytotoxic drug.
The cytotoxic drug Docetaxel ( a standard chemotherapeutic drug ) was included as a positive control.
In some embodiments, the drug is a cytotoxic drug.
In such instances the t ½ of cytotoxic drug release was substantially less than 10 minutes.
In one embodiment, the drug is a cytotoxic drug.
It also contains the cytotoxic drug DM1, which inhibits tumor cell division.
The prodrug is relatively non-toxic compared to the cytotoxic drug.
Mild diabetes was induced by beta cytotoxic drug ( streptozotocin ) at birth.
For example, a biMab comprising an scFv may be conjugated to a cytotoxic drug.
Enzalutamide ( Enza ) a potent anti prostate cytotoxic drug is used as positive control.
In one embodiment, the anti-rheumatic agent is an immunosuppressive cytotoxic drug.
BM1EE is known to be a more potent cytotoxic drug than bendamustine.
In view of the results of this example, methotrexate is a compatible cytotoxic drug.
In some aspects of the invention, the cytotoxic drug is an anti-tubulin agent.
In view of the results of this example, cisplatin is not a compatible cytotoxic drug.
A pharmaceutical composition of claim 6, further comprising a cytotoxic drug in a pharmacologically effective amount.
The pharmaceutical bag according to claim 1, wherein the pharmaceutical product is a cytotoxic drug.
Silicon implants comprising a radionucleotide and / or a cytotoxic drug and their use in cancer treatment.
The isolated antibody according to claim 8, wherein said functional label is a cytotoxic drug.
For example, Cys residue can be coupled to a cytotoxic drug to form a drug conjugate.
Immunoconjugates are made of a human, humanized or chimeric recombinant antibody, covalently linked to a cytotoxic drug.
The compound of claim 1, wherein the cytotoxic drug is a maytansinoid.
In any of the various embodiments discussed herein, the pharmaceutical product is a cytotoxic drug.
A positive control of metronidazole, a well-known cytotoxic drug against parasites, was used as a reference.
The cytotoxic moiety may be capable of converting a non-cytotoxic prodrug into a cytotoxic drug.
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