Examples of 'debenzylation' in a sentence
Meaning of "debenzylation"
Debenzylation (noun): The removal of a benzyl group from a molecule
Show more definitions
- Any reaction that removes one or more benzyl groups from a molecule
How to use "debenzylation" in a sentence
Basic
Advanced
debenzylation
The debenzylation is carried out in conventional manner.
Glycosylation is then followed by debenzylation by suitable treatment.
Final debenzylation was carried out as described below.
A radical approach to debenzylation of amides.
The debenzylation may be vía catalytic hydrogenation.
These two compounds are used respectively in the final debenzylation step.
Debenzylation subsequently provides the dihydrochloride.
The filtrate was used for the transfer hydrogenation debenzylation reaction.
After debenzylation the catalyst may be removed by filtration.
Other reagents that can facilitate catalytic debenzylation can also be used.
This is a debenzylation in most cases.
Partial dehydroxylation of benzyl hydroxy group also took place during the debenzylation reaction.
Hydrogenolytical debenzylation and hydrochloric acid created the final product.
The crude product was carried through to the debenzylation step before purification.
The debenzylation of the invention can also be carried out en masse.
See also
Such a hydrolysis is usually carried out before the catalytic debenzylation process referred to above.
The debenzylation can be carried out accroding to the well known methods.
Compounds of interest Iaa can be prepared by standard debenzylation of IIaa.
Debenzylation of the amine allows for the elaboration of the second nitrogen atom.
This step consists of deprotection of the DTPA grafted on the polymer by debenzylation.
Coupling of fluorides IIao with amines XVI followed by debenzylation affords compounds of interest Ial.
Debenzylation is carried out in the following manner,.
Compounds Lbj can be prepared by standard debenzylation of Ibi.
Subsequent debenzylation generates amines Lbj.
This is equivalent to a deprotection which, in the example above, is selective debenzylation.
The compound of formula I is subjected to debenzylation to form the compound of formula IV.
Debenzylation was completed in about 3 hours.
In one embodiment, the debenzylation is vía catalytic hydrogenation.
Debenzylation by standard methods described above provides a compound of formula 43.
In a preferred embodiment, the debenzylation is performed by catalytic hydrogenation.
Debenzylation was completed in about 3 hours and then the catalyst was filtered off.
Reduction of the imide, and selective debenzylation are accomplished as described therein.
When a debenzylation occurs, a quantitative re-benzylation can be carried out by a simple reaction.
Thus this procedure introduces two additional steps in the synthesis, a benzylation and a debenzylation step.
Wherein the debenzylation is carried out in the presence of sec-butanol.
The method of Claim 9 wherein the debenzylation is by hydrogenation.
Only after the debenzylation d - nebivolol and i - nebivolol are mixed to a racemate.
The deprotecting the N-protected aminosulfone may be vía debenzylation.
Alternatively, the debenzylation can be carried out by the following successive operations,.
In one embodiment, the deprotecting the N-protected aminosulfone is vía debenzylation.
The term " debenzylation " refers to the cleavage of a benzyl substituent from a compound.
The reaction can be carried out in analogy to debenzylation of IIaa in Scheme 4.
LCMS suggested debenzylation was complete after 2 hours.
A preferred protection method is the benzylation and following debenzylation on Pd / C in tetrahydrofuran.
However, debenzylation of benzyl aryl ethers may be accomplished with SMEAH.
The process according to Preferred embodiment 9 wherein the debenzylation is performed by catalytic hydrogenation.
Debenzylation according to the same process as in Example 20 provides the tetrahydrochloride.
This process, which involves subsequent debenzylation is laborious and not very suitable for industrial-scale production.
Debenzylation according to the same process as in Example 22 provides the dihydrochloride.
LCMS analysis showed that the debenzylation was complete . The filtrate was concentrated.
