Examples of 'diabodies' in a sentence
Meaning of "diabodies"
diabodies (noun) - Diabodies are small antibody fragments composed of two antibody variable domains. They are often used in medical research and therapy as they can target specific antigens with high affinity
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- plural of diabody
How to use "diabodies" in a sentence
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diabodies
Diabodies are dimers composed of two polypeptide chains.
Single chain antibodies and diabodies are described.
The tandem diabodies are devoid of immunoglobulin constant domains.
The present invention also encompasses diabodies.
Covalent diabodies and uses thereof.
Also included in antibody fragments are diabodies.
Diabodies may be bivalent or bispecific.
Formats for agglutination using diabodies.
Diabodies can be bispecific or monospecific.
In some embodiments the antibodies are diabodies.
Diabodies may be bivalent or bispecifc.
Agglutination by bivalent and bispecific diabodies.
Diabodies may be monospecfic or bispecific.
This type is known as diabodies.
Diabodies may additionally be stabilised by the incorporation of disulphide bridges.
See also
Construction of minus linker diabodies.
Diabodies are discussed further infra.
The conservative derivatives of the invention also include diabodies.
Diabodies have two chains.
They exhibit an even higher affinity to their targets than diabodies.
Diabodies are dimeric scFvs.
This indicates the presence of bispecific diabodies in the periplasmic preparation.
Diabodies are a new class of small bivalent and bispecific antibody fragments.
Some utilities of diabodies.
Diabodies may bind to one ore more than one epitope.
Structure of diabodies.
Bivalent diabodies have wide ranging applications including therapy and immunodiagnosis.
It may be preferable to use scFv dimers or diabodies rather than whole antibodies.
The structure of diabodies is compact and with short linkers should be rigid.
The aim was to investigate the constructional constraints that operate on bispecific diabodies.
Diabodies comprise two molecules of scFv and thus have four variable regions.
The skilled artisan will appreciate that any method to generate diabodies can be used.
The diabodies of the disclosure can be used to treat a variety of diseases and disorders.
The invention relates to new tandem Fv diabodies and uses thereof.
The diabodies are constructed through common intermediates and will therefore described together.
The SAP binding antibodies and fragments also encompass diabodies.
The bispecific diabodies of the disclosure can simultaneously bind two separate and distinct epitopes.
In some embodiments, the antibody fragments are diabodies.
This selection proves that diabodies can be selected from repertoires using the standard phage format.
In the context of the present invention, diabodies can be used.
Diabodies are similar in size to a Fab fragment.
A detailed description of diabodies can be found in Holliger P et al.
Diabodies are similar in size to an Fab fragment.
For example, bispecific diabodies have minimal size.
The diabodies consist of two Fv fragments having different specificities.
Discussion of construction of repertoires of diabodies and their display on bacteriophage ;.
Diabodies are more fully described in POLJAK.
Compared to tPA, the diabodies show a reduction in bleeding time.
In some embodiments, the antibody fragments of the invention are diabodies.
Further, diabodies and triabodies are also included.
