Examples of 'diketopiperazine' in a sentence
Meaning of "diketopiperazine"
Diketopiperazine: a chemical compound with a cyclic structure containing two ketone groups
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- Any of a family of heterocycles that are simple cyclic peptides; many have significant biochemical activity.
How to use "diketopiperazine" in a sentence
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diketopiperazine
The peptide is thereby complexed to the diketopiperazine.
Diketopiperazine salts for drug delivery.
Wherein the heterocyclic compound comprises a diketopiperazine.
Microparticles comprising diketopiperazine salts for drug delivery.
Pharmaceutique formulations comprising insulin complexed with a diketopiperazine.
The insulin complexed to a diketopiperazine may be monomeric insulin.
A preferred transport enhancer is fumaryl diketopiperazine.
Microcrystalline diketopiperazine compositions and methods.
Pharmaceutical formulations comprising a peptide complexed with a diketopiperazine.
The carboxylate group of the diketopiperazine may be terminally located.
Pharmaceutical formulations comprising insulin complexed with a diketopiperazine.
Diketopiperazine salts for drug delivery and related methods.
In some embodiments the nanoparticle clusters comprise fumaryl diketopiperazine.
Substituted diketopiperazine analogs for use as drug delivery agents.
Other complexing agents may be substituted for the diketopiperazine.
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These substituted diketopiperazine compounds have utility as drug delivery agents.
The peptide or protein is thereby complexed to the diketopiperazine microparticles.
Ring cyclization to form the diketopiperazine is accomplished by intramolecular amine attack on the ester.
The cyclic arrangement that is the prelude to diketopiperazine formation.
The general formula for diketopiperazine and its analogs is shown below.
Any form of an active agent can be combined with a diketopiperazine.
Both moexipril and moexiprilat are converted to diketopiperazine derivatives and unidentified metabolites.
Insulin has been found to be stabilized within an ordered lattice array of fumaryl diketopiperazine.
The combination of a drug and a diketopiperazine can impart improved drug stability.
The resulting product is also an asymmetric partially deprotected diketopiperazine derivative.
The diketopiperazine microparticles have been found to have a higher affinity for insulin than does zinc.
Ramipril rapidly undergoes decomposition leading to diketopiperazine as decomposed product.
The monoprotected diketopiperazine is reacted to produce a diketopiperazine with one sidechain and protecting group.
Very little is known regarding the physiological role of diketopiperazine derivatives.
Ii obtaining preformed diketopiperazine crystalline microparticles ;.
Some or all of the insulin molecules then bind to the diketopiperazine particles.
In a preferred option, the diketopiperazine is fumaryl diketopiperazine.
The peptide was coupled to the solid phase support using a diketopiperazine linker.
In a preferred embodiment, the diketopiperazine is fumaryl diketopiperazine.
Higher temperatures are inadvisable since they lead to cyclization of the product to a diketopiperazine derivative.
The percentage of diketopiperazine was calculated as area %.
The following examples are included to demonstrate embodiments of the disclosed microcrystalline diketopiperazine particles.
Providing a fumaryl diketopiperazine in solution ;.
Preferably different blocking groups are used to block the nucleophiles of the different diketopiperazine linkers.
Zwitterionic diketopiperazine derivatives can also be selectively deprotected, as described above.
The method of any preceding claim wherein the diketopiperazine is fumaryl diketopiperazine.
The inhalable dry powder formulation of the first aspect of the present invention comprises a diketopiperazine.
Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery.
These formulations include microparticles formed of a diketopiperazine and insulin coated thereon.
Active Agents Options of the present disclosure employ particles combining an active agent with a diketopiperazine.
The use according to claim 3 wherein said diketopiperazine is fumaryl diketopiperazine.
MATERIALS AND METHODS A random peptide library of this invention was synthesized with a hydrolyzable diketopiperazine linker.
The crystalline diketopiperazine composition of claim 3, wherein the peptide is an endocrine hormone.
Composition comprising a serotonin receptor agonist and a diketopiperazine for treating migraines.
Microparticles comprising diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery.
