Examples of 'dissociation rate' in a sentence
Meaning of "dissociation rate"
dissociation rate: In the context of chemistry or physics, it refers to the speed or frequency at which a compound breaks down or separates into its components
How to use "dissociation rate" in a sentence
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dissociation rate
A low dissociation rate may lead to persistence.
These sensorgrams were used to generate the dissociation rate.
A slow dissociation rate is usually predictive of high affinity.
These aptamers are screened to identify slow dissociation rate aptamers.
Dissociation rate decreased with lower antibody concentrations.
This is reflected in a very low dissociation rate of the complex.
The dissociation rate can be measured by surface plasmon resonance.
The fluid aspiration rate is matched to the tissue dissociation rate.
Calculated dissociation rate constants were ranked from slowest to fastest.
An example of determining binding affinity and dissociation rate is described below in Example II.
The dissociation rate also can be measured by BIAcore or KinExA technology.
Methods for determining association and dissociation rate constants are well known in the art.
The dissociation rate covers a two orders of magnitude decrease in complex stability.
The association rate constant and the dissociation rate constant both accelerate with increasing temperature.
Antibodies with similar KD can have widely variable association and dissociation rate constants.
See also
The dissociation rate constant is calculated from the slope of the line.
Confirmed positive hybridoma clones were selected and subjected to binding dissociation rate ranking by Biacore.
This dissociation rate was fit to a exponential decay model and the kd calculated.
Interactions with the same KD can have widely variable association and dissociation rate constants.
Substrate dissociation rate contributes to how large or small the enzyme velocity will be.
In another embodiment, binding affinity is measured by an antigen / antibody dissociation rate.
Equilibrium dissociation rate constants may be calculated to evaluate the strength of the binding interaction.
In another example, binding affinity is measured by an antigen / antibody dissociation rate.
A low dissociation rate in combination with a high association rate tends to provide potent therapeutic entities.
In another aspect, binding affinity is measured by an antigen / antibody dissociation rate.
The dissociation rate constant is defined using Koff.
Preferably, the binding affinity and dissociation rate is measured by surface plasmon resonance.
These data were fitted to a single exponential curve to determine the dissociation rate constants ( koff ).
This decreased dissociation rate was accompanied by a two-fold decrease in the association rate.
In another disclosure, the binding affinity and dissociation rate is measured using a BIAcore.
Association and dissociation rate constants were measured, from which binding constants were determined.
In particular, aggregates cause artifactually slow association and dissociation rate constants to be detected.
Figure 2 shows different dissociation rate constants for different CDR-shuffled clones.
This is because the substrate recognition molecule has a lower dissociation rate ( kd ) than the enzyme.
Binding association rate, dissociation rate and the overall affinity were calculated in BIAevaluation.
Kinetic analysis using BIAevaluation ™ software was performed to obtain the association and dissociation rate constants.
However, the dissociation rate constants are inversely correlated with the fiber knob affinities.
Accordingly, salts may be selected based on their dissociation rate in an enzymatic reaction medium.
Koff refers to the dissociation rate constant of a particular antibody-antigen interaction or antibody fragment-antigen complex.
More preferably, the binding affinity and dissociation rate are measured using BIACORE ™.
The dissociation rate of UL9-COOH changes markedly under different physical conditions.
Ka is the antibody 's association rate constant and Kd is the antibody 's dissociation rate constant.
A dissociation rate constant can be measured by surface plasmon resonance, for example using the BIACORE ™.
Disclosed is an antigen binding protein that has a low dissociation rate from PAR-2.
The dissociation rate constant was calculated with BIAevaluation software ( GE Healthcare ).
The Fab mutants generally had very similar association and dissociation rate constants, kon and koff.
Apparent dissociation rate constants of the interaction between D2E7 and biotinylated rhTNF Experiment.
In some embodiments, the anti-M-CSF antibody has a low dissociation rate.
Results Dissociation rate analysis of VEGF-A antagonists to human VEGF-A was determined.
In another aspect of the invention, the anti-IGF-IR antibody has a low dissociation rate.
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A dissociation constant is the reciprocal of an association constant
Examples of using Rate
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