Examples of 'domain antibody' in a sentence
Meaning of "domain antibody"
Domain antibody: A type of antibody engineered for specific applications, often used in research, diagnostics, or therapeutics
How to use "domain antibody" in a sentence
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domain antibody
The domain antibody solution can be oxygenated.
In one example the single domain antibody is humanised.
It is feasible to provide a modular antibody as a single domain antibody.
Domain antibody of the invention.
Effect of PEGylation on the salting out of a domain antibody.
The domain antibody may also be present in physiological saline.
Synthetic single domain antibody.
The domain antibody may also be transferred into physiological saline.
In a particular embodiment said single domain antibody is derived from camelids.
In a preferred embodiment this treatment will be applied to purified domain antibody.
Single domain antibody fragments were subcloned in the pAOCAT bacterial periplasm expression vector.
The host of the present invention will be capable of producing a domain antibody.
Preferably the domain antibody is present in a buffer that does not contain any phosphates.
It is feasible to provide the preferred modular antibody disclosed herein as a single domain antibody.
A single domain antibody comprises a single antigen binding site comprising a single domain.
See also
This does not exclude that said single domain antibody also binds to other antigens.
A single domain antibody as employed to herein does not refer to a single chain Fv.
The antibody according to the invention may also be a single domain antibody or a fragment thereof.
Said single VI domain antibody comprises a heterodimer.
PEGylation can also be mediated through a peptide linker attached to a domain antibody.
The antibody polypeptides disclosed herein may be a domain antibody containing a single variable domain.
Generally, a domain antibody may comprise a universal framework.
Such unique features provide highly stable synthetic single domain antibody with low risk of immunogenicity.
Hence, the domain antibody can be co-expressed in the host with a thiol isomerase.
The PEG polymer may be linked to a domain antibody at a predetermined position.
The antibody may be a monoclonal, polyclonal or single domain antibody.
The two VH regions of a bivalent domain antibody can target the same or different antigens.
Alternatively, the specific binding member may be a single domain antibody.
An example of a synthetic single domain antibody scaffold is shown in figure 1.
This is beneficial e.g. in the context a therapeutic application of the domain antibody.
In one aspect, the domain antibody comprises a universal framework.
In another embodiment, the antibody according to the invention is a single domain antibody.
A method of making a synthetic single domain antibody library, said method comprising.
Applying these conditions will also be referred to as “ treatment ” of the domain antibody.
The single domain antibody may be derived from a rodent, a human or other species.
Isolating and / or purifying the secreted domain antibody from the medium.
Generally, the domain antibody of the dual specific ligand may comprise a universal framework.
The nucleic acid molecule of claim 1, wherein each single domain antibody is humanised.
Subsequent to refolding, the domain antibody can be transferred to a new buffer system, if desired.
Since this antibody fragment consists of only one domain, it is called single domain antibody.
Western blot analysis using an anti-Gla domain antibody shows expression of the variants.
In some embodiments, the ligand is a monoclonal antibody, a single chain antibody or a single domain antibody.
In a further embodiment, the domain antibody can comprise a binding site for a generic ligand.
Functional antibody fragments include is a UniBody, a domain antibody or a Nanobody.
For example, the domain antibody of the present invention is advantageous for therapeutic applications.
In one embodiment of the dual specific ligand, the domain antibody comprises a universal framework.
The domain antibody comprises a single immunoglobulin variable domain that binds CD28.
A fusión protein according to claim 1 wherein each single domain antibody is fully human or humanised.
Said single VI domain antibody comprises a homodimer ; or.
In a further embodiment, the at least one single domain antibody is a humanized VHH.
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All domain names must be in upper case
In the educational domain projects under way
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Examples of using Antibody
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Antibody status should be monitored and reported
The kinetics of antibody decline are also similar
Antibody persistence after booster immunisation adults
