Examples of 'drug moiety' in a sentence
Meaning of "drug moiety"
drug moiety: Refers to a portion or component of a drug compound, especially in pharmacology and chemistry contexts
How to use "drug moiety" in a sentence
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drug moiety
Doses are expressed as weight of the active drug moiety.
Aripiprazola is the predominant drug moiety in the systemic circulation.
The drug moiety is not to be construed as limited to classical chemical therapeutic agents.
Such aldehyde can be reacted with a drug moiety or linker nucleophile.
The drug moiety may be directly or indirectly linked to the carrier moiety.
In one aspect the maytansinoid drug moiety has the following stereochemistry.
A drug moiety may be attached to the engineered cysteine group in the heavy chain.
The biological activity of the drug moiety is thus modulated by conjugation to an antibody.
A drug moiety may be attached the an engineered cysteine group in the light chain.
D is a drug moiety.
The drug moiety is then attached to the antibody using chemistries standard in the art.
Metabolic cleavage may also result in the production a drug moiety or part thereof.
The drug moiety represented by D may be a releasable NSAID analogue.
These parameters must be tailored for each drug moiety to be used with these devices.
The drug moiety reagents include the compounds,.
See also
In another preferred embodiment, the targeting moiety is a drug moiety.
Embodiments of drug moiety reagents include the compounds,.
The antibody drug conjugate, wherein the drug moiety is a maytansinoid.
The drug moiety may be attached to either end of the carrier moiety e . g.
D is a nemorubicin metabolite or analog drug moiety having the structure, wherein,.
In some embodiments, the antibody further comprises a conjugated drug moiety.
The drug moiety includes calicheamicin, and analogs and derivatives thereof.
In any of the immunoconjugates described above, the antibody may be conjugated to a drug moiety.
Preferably, the drug moiety is attached to the amino terminal end of the carrier.
The method of claim 1 wherein the human or humanized antibody is conjugated to a drug moiety.
Advantageously, the drug moiety is chosen from among the following moieties, and.
In some embodiments, the antibody is covalently attached to the drug moiety through a linker.
For example, the drug moiety may be a protein or polypeptide possessing a desired biological activity.
Effector or reporter molecules include a molecule such as a cytotoxic agent, a radionuclide or drug moiety.
The release of the drug moiety is based on the self-elimination reaction of aminobenzyloxycarbonyl group.
Dimethyl formamide ( DMF ) may also be employed to dissolve the drug moiety reagent.
The conjugated NSAID drug moiety is represented by the group " D " in formulae described herein.
The use according to claim 8, wherein the drug moiety is a toxin.
Drug Moiety Reagents The nemorubicin metabolite and analog drug moiety reagents have the structure,.
A " self-immolative " spacer unit allows for release of the drug moiety.
D is a drug moiety selected from Formulas DE and DF, and.
A " self-immolative " spacer unit allows for release of the drug moiety without a separate hydrolysis step.
A preferred drug moiety D is a DNA minor groove binder / alkylator.
The linker, I, attaches the antibody to a drug moiety through covalent bond ( s ).
The drug moiety metabolite may be linked to a part, or all, of the linker.
P is an integer of from 1 to about 20 ; and D is a drug moiety having Formula D,.
The location of the drug moiety can thus be designed, controlled, and known.
P is an integer ranging from 1 to about 20 ; and D is a drug moiety having Formula D,.
D is a drug moiety of the following formula ( II ), wherein,.
II-The Drug ( D ) The drug moiety according to the invention has the following formula ( II ).
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Examples of using Moiety
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No aromatic or heteroaromatic moiety as a component of an ester or acetal
These dissimilar parts are connected by a glycerol moiety
No aromatic or heteroaromatic moiety as a component of an ester or ketal
