Examples of 'effector function' in a sentence
Meaning of "effector function"
effector function: In physiology or biology, this phrase refers to the capability of a molecule, cell, or organ to produce a specific effect or response. It is the activity or role that causes a physiological or biochemical change
How to use "effector function" in a sentence
Basic
Advanced
effector function
Potential role in regulating helper effector function.
T cell effector function was also monitored by cytokine secretion.
Phagocytosis assays to determine antibody effector function.
To recruit an effector function or the like.
Different isotypes have different effector function.
A hinge may have effector function or be deprived of effector function.
The antibody may have effector function.
Effector function engineering.
This mutation results in reduced effector function.
Effector function can also be influenced by mutations in the hinge region.
An antibody may have no effector function.
Increased effector function can be measured by methods known in the art.
In one embodiment the antibody has no effector function.
Methods for determining effector function are known in the art.
In certain instances it is advantageous to decrease or eliminate effector function.
See also
In some embodiments it has effector function and can fix complement.
Such a mode of treatment may enhance desired effector function.
In some aspects it has effector function and can fix complement.
The second antibody may be an antibody with effector function.
Antibodies without effector function exhibited efficacy in inhibiting tumor growth.
In one embodiment the antibody is effector function silent.
In general increased effector function would be directed to tumor and foreign cells.
Fc domain modifications identified as altering effector function are disclosed above.
This cytolytic effector function does not require prior sensitization or antigen presentation by accessory cells.
Such a mode of treatment may limit unwanted effector function.
Such molecules preferably mediate effector function more effectively as discussed infra.
Particular antibodies of the invention exhibit reduced effector function.
In a preferred embodiment it has effector function and can fix complement.
In one embodiment the bispecific antibody is free of effector function.
Another potential means of modulating effector function of antibodies includes changes in glycosylation.
The constant regions are typically responsible for effector function.
Such cells have highly desirable effector function and patient safety characteristics.
Disclosed herein are heteromultimer constructs with reduced or silenced effector function.
Such substitutions may alter effector function while retaining antigen binding activity.
In one embodiment both antibodies in the complex are effector function silent.
These cells exert an immediate effector function upon antigen stimulation by releasing cytotoxic mediators.
The mutation results in an antibody that has an altered effector function.
In one embodiment the antibody has effector function and can fix complement.
In one embodiment both antibodies of the complex have no effector function.
Methods of assessing effector function are described in Jiang et al.
Modulation of a costimulatory signal results in modulation of effector function of an immune cell.
Altered effector function Other modifications of the antibody are contemplated.
Another disadvantage to using scFv for therapy is the lack of effector function.
In one embodiment the reduced effector function is reduced ADCC.
The heavy chain constant region is primarily responsible for effector function.
In one embodiment the increased effector function is increased ADCC.
Those native structures either remain unchanged or are modulated for an increased effector function.
Cells which acquire cytotoxicity vía antibody effector function are called effector cells.
A principal effector function of the GDNFRa is its ability to bind GDNF.
Such differences can lead to changes in both effector function and pharmacokinetics.
You'll also be interested in:
Examples of using Effector
Show more
In an effector cell aimed at destroying the pathogens
Sensory reception and effector control are stressed
The effector cell may be an immune cell
Examples of using Function
Show more
He could not function any other way
Function keys with preset multimedia actions
The desired function word will flash
