Examples of 'eliglustat' in a sentence
Meaning of "eliglustat"
Eliglustat is a noun that refers to a medication used to treat Gaucher disease
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- A drug used to treat Gaucher's disease, commonly used as the tartrate salt.
How to use "eliglustat" in a sentence
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eliglustat
Cerdelga contains the active substance eliglustat.
Crystalline eliglustat hydrochloride is described and characterized herein.
Agents whose exposure may be increased by eliglustat.
It is unknown whether eliglustat or its metabolites are excreted in human milk.
Food does not have a clinically relevant effect on eliglustat pharmacokinetics.
Placental transfer of eliglustat and its metabolites was shown in the rat.
There is limited experience in the treatment of elderly with eliglustat.
The active substance is eliglustat as tartrate.
Use of eliglustat under these conditions results in substantially elevated plasma concentrations of eliglustat.
Agents that may increase eliglustat exposure.
One patient in the eliglustat treated group discontinued at six months for personal reasons.
Agents that may decrease eliglustat exposure.
Eliglustat did not have effects on CNS or respiratory functions.
Manufacturing costs for eliglustat are slightly lower than for imiglucerase.
Eliglustat is a substrate of the efflux transporter P-gp.
See also
Crystalline eliglustat hydrochloride.
In one embodiment, the agent for substrate reduction therapy is Miglustat or Eliglustat.
Always consult the doctor who prescribed eliglustat before you start using other medicines.
Crystalline eliglustat hydrochloride of the invention is useful in the treatment of Gaucher disease.
Nonclinical studies demonstrated a wide distribution of eliglustat to tissues, including bone marrow.
However, eliglustat is not a cure for this condition.
In order to investigate the long-term safety of eliglustat in patients prescribed eliglustat, the.
The crystalline eliglustat hydrochloride according to any one of items 1 or 2 in pure form.
Use of a moderate CYP3A inhibitor with eliglustat is not recommended in PMs.
The crystalline eliglustat hydrochloride according to item 1, which is a hydrate.
Each capsule contains 84 mg of eliglustat as tartrate.
This patient is using eliglustat ( Cerdelga ) for the treatment of Gaucher Disease type 1.
FIG . 2 . illustrates the thermogravimetric differential thermal analysis ( TG-DTA ) thermogram of crystalline eliglustat hydrochloride.
XRPD analysis of the remaining solid eliglustat hydrochloride was consistent with Eliglustat hydrochloride form A.
Eliglustat is also contraindicated in patients who are CYP2D6 poor metabolisers taking a strong CYP3A inhibitor.
In one embodiment of the disclosure, crystalline eliglustat hydrochloride is provided in substantially pure form.
Cerdelga 84 mg hard capsules eliglustat.
The present invention relates to crystalline eliglustat hydrochloride, in particular to a crystalline eliglustat hydrochloride hydrate.
Concomitant administration of substances affecting CYP2D6 or CYP3A4 activity may alter eliglustat plasma concentrations.
Eliglustat free base was isolated as a free flowing white powder in ∼ 54 % yield.
Aqueous solubility was determined gravimetrically by slurrying Eliglustat hydrochloride from example 1 in water at 22°C.
Eliglustat is extensively metabolized with high clearance, mainly by CYP2D6 and to a lesser extent CYP3A4.
Each capsule contains 84 mg eliglustat.
The recommended dose is 84 mg eliglustat once daily in CYP2D6 poor metabolisers PMs.
Two drugs in this class are miglustat ( Zavesca ) and eliglustat ( Cerdelga ).
The crystalline eliglustat hydrochloride according to item 10, the X-ray powder diffraction spectrum shown in FIG . 1.
After intravenous administration, eliglustat total body clearance was 86 L / h.
Eliglustat is metabolised primarily by CYP2D6 and to a lesser extent by CYP3A4.
